TY - JOUR
T1 - Development, validation, qualification, and dissemination of quantitative MR methods
T2 - Overview and recommendations by the ISMRM quantitative MR study group
AU - Weingärtner, Sebastian
AU - Desmond, Kimberly L.
AU - Obuchowski, Nancy A.
AU - Baessler, Bettina
AU - Zhang, Yuxin
AU - Biondetti, Emma
AU - Ma, Dan
AU - Golay, X
AU - Boss, M A
AU - More Authors, null
PY - 2021
Y1 - 2021
N2 - On behalf of the International Society for Magnetic Resonance in Medicine (ISMRM) Quantitative MR Study Group, this article provides an overview of considerations for the development, validation, qualification, and dissemination of quantitative MR (qMR) methods. This process is framed in terms of two central technical performance properties, i.e., bias and precision. Although qMR is confounded by undesired effects, methods with low bias and high precision can be iteratively developed and validated. For illustration, two distinct qMR methods are discussed throughout the manuscript: quantification of liver proton-density fat fraction, and cardiac T1. These examples demonstrate the expansion of qMR methods from research centers toward widespread clinical dissemination. The overall goal of this article is to provide trainees, researchers, and clinicians with essential guidelines for the development and validation of qMR methods, as well as an understanding of necessary steps and potential pitfalls for the dissemination of quantitative MR in research and in the clinic.
AB - On behalf of the International Society for Magnetic Resonance in Medicine (ISMRM) Quantitative MR Study Group, this article provides an overview of considerations for the development, validation, qualification, and dissemination of quantitative MR (qMR) methods. This process is framed in terms of two central technical performance properties, i.e., bias and precision. Although qMR is confounded by undesired effects, methods with low bias and high precision can be iteratively developed and validated. For illustration, two distinct qMR methods are discussed throughout the manuscript: quantification of liver proton-density fat fraction, and cardiac T1. These examples demonstrate the expansion of qMR methods from research centers toward widespread clinical dissemination. The overall goal of this article is to provide trainees, researchers, and clinicians with essential guidelines for the development and validation of qMR methods, as well as an understanding of necessary steps and potential pitfalls for the dissemination of quantitative MR in research and in the clinic.
KW - bias
KW - confounding factors
KW - PDFF
KW - precision
KW - quantitative
KW - T
UR - http://www.scopus.com/inward/record.url?scp=85120034097&partnerID=8YFLogxK
U2 - 10.1002/mrm.29084
DO - 10.1002/mrm.29084
M3 - Article
AN - SCOPUS:85120034097
SN - 0740-3194
VL - 87
SP - 1184
EP - 1206
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
IS - 3
ER -