Direct covalent attachment of silver nanoparticles on radical-rich plasma polymer films for antibacterial applications

Behnam Akhavan, Sadra Bakhshandeh, Hamed Najafi-Ashtiani, Ad C. Fluit, Edwin Boel, Charles Vogely, Bart C.H. van der Wal, Amir Zadpoor, Harrie Weinans, Wim E. Hennink, Marcela Bilek, Saber Amin Yavari

Research output: Contribution to journalArticleScientificpeer-review

9 Citations (Scopus)

Abstract

Prevention and treatment of biomaterial-associated infections (BAI) are imperative requirements for the effective and long-lasting function of orthopedic implants. Surface-functionalization of these materials with antibacterial agents, such as antibiotics, nanoparticles and peptides, is a promising approach to combat BAI. The well-known silver nanoparticles (AgNPs) in particular, although benefiting from strong and broad-range antibacterial efficiency, have been frequently associated with mammalian cell toxicity when physically adsorbed on biomaterials. The majority of irreversible immobilization techniques employed to fabricate AgNP-functionalized surfaces are based on wet-chemistry methods. However, these methods are typically substrate-dependent, complex, and time-consuming. Here we present a simple and dry strategy for the development of polymeric coatings used as platforms for the direct, linker-free covalent attachment of AgNPs onto solid surfaces using ion-assisted plasma polymerization. The resulting coating not only exhibits long-term antibiofilm efficiency against adherent Staphylococcus aureus (S. aureus), but also enhances osteoblast adhesion and proliferation. High resolution X-ray photoelectron spectroscopy (XPS), before and after sodium dodecyl sulfate (SDS) washing, confirms covalent bonding. The development of such silver-functionalized surfaces through a simple, plasma-based process holds great promise for the fabrication of implantable devices with improved tissue-implant integration and reduced biomaterial associated infections.
Original languageEnglish
Pages (from-to)5845-5853
JournalJournal of Materials Chemistry B
Volume8
Issue number37
DOIs
Publication statusPublished - 2018

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    Akhavan, B., Bakhshandeh, S., Najafi-Ashtiani, H., Fluit, A. C., Boel, E., Vogely, C., van der Wal, B. C. H., Zadpoor, A., Weinans, H., Hennink, W. E., Bilek, M., & Amin Yavari, S. (2018). Direct covalent attachment of silver nanoparticles on radical-rich plasma polymer films for antibacterial applications. Journal of Materials Chemistry B, 8(37), 5845-5853. https://doi.org/10.1039/C8TB01363B