Abstract
Viruses can induce oncogenic mutations when inserted near (or within) proto-oncogenes. Cancer genes can be identified by determining the loci of viral
insertions from tumors induced by retroviruses. Most often, multiple co-occurring mutations are needed for a cell to develop into a tumor. We propose a 2D Gaussian Kernel Convolution method to discover the cooperating oncogenes from publicly available retroviral insertional mutagenesis data.
insertions from tumors induced by retroviruses. Most often, multiple co-occurring mutations are needed for a cell to develop into a tumor. We propose a 2D Gaussian Kernel Convolution method to discover the cooperating oncogenes from publicly available retroviral insertional mutagenesis data.
| Original language | English |
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| Number of pages | 1 |
| Publication status | Published - 2006 |
