Dorsal root ganglion (DRG) versatile stimulator prototype developed for use in locomotion recovery early clinical trials

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Abstract

This paper presents the development of a Dorsal Root Ganglion (DRG) stimulator system intended for use in early clinical trials for motor recovery after Spinal Cord Injury (SCI). It allows for independent control of multisite/multilevel bilateral (on both sides of the spinal cord) stimulation, it can supply a high output current of 25.4mA, and has the ability to program pulse sequences similar to actual locomotion patterns. These characteristics ultimately provide the required versatility for examining the effects of DRG stimulation on locomotion recovery, which is lacking in currently available commercial systems. The device is created using commercially available components to make the design reproducible by other research labs and to facilitate the critical approval procedure for use in a clinical research environment. Throughout the design phase, essential considerations regarding the safety of the participating patient, as well as of the medical personnel involved, were taken into account and these are analyzed and demonstrated in this paper. Such considerations are very rarely discussed in scientific literature and the authors consider that, apart from the design of the system itself, this discussion is a critical contribution of this paper.

Original languageEnglish
Title of host publication2021 10th International IEEE/EMBS Conference on Neural Engineering (NER)
PublisherIEEE
Pages1125-1129
Number of pages5
ISBN (Electronic)978-1-7281-4337-8
ISBN (Print)978-1-7281-4338-5
DOIs
Publication statusPublished - 2021
Event10th International IEEE/EMBS Conference on Neural Engineering, NER 2021 - Virtual, Online, Italy
Duration: 4 May 20216 May 2021

Conference

Conference10th International IEEE/EMBS Conference on Neural Engineering, NER 2021
CountryItaly
CityVirtual, Online
Period4/05/216/05/21

Bibliographical note

Accepted author manuscript

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