Dynamic arm study: Quantitative description of upper extremity function and activity of boys and men with duchenne muscular dystrophy

Mariska M.H.P. Janssen*, Jaap Harlaar, Bart Koopman, Imelda J.M. De Groot

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

14 Citations (Scopus)

Abstract

Background: Therapeutic management of upper extremity (UE) function of boys and men with Duchenne Muscular Dystrophy (DMD) requires sensitive and objective assessment. Therefore, we aimed to measure physiologic UE function of healthy subjects and DMD patients in different disease stages, and to evaluate the relation between these physiologic measures and functional UE scales. Methods: Twenty-three DMD patients and twenty healthy controls (7-23 years) participated in this explorative case-control study. Maximal muscle torque, maximal and normalized surface electromyography (sEMG) amplitudes, muscle thickness, echogenicity and maximal passive and active joint angles were measured. At activity level, Brooke upper extremity rating scale and the Performance of Upper Limb (PUL) scale were used. Results: Outcome measures related to proximal UE function could discriminate between disease stages. Increased normalized sEMG amplitudes were found in patients, even in early disease stages. Maximal active joint angles showed the strongest relation to Brooke scale (R 2 = 0.88) and PUL scale (R 2 = 0.85). Conclusions: The decline of muscle functions precedes the decline in performance of UE activities, and therefore may play a role in early detection of UE limitations. Increased sEMG levels demonstrate that DMD patients use more of their muscle capacity compared to healthy subjects, to perform daily activities. This might result in increased fatigability. Active maximal joint angles are highly related to functional scales, so preserving the ability to use the full range of motion is important for the performance of daily activities. Close monitoring of active joint angles could therefore help in starting interventions that minimize functional UE decline in DMD patients timely.

Original languageEnglish
Article number45
Number of pages14
JournalJournal of NeuroEngineering and Rehabilitation
Volume14
Issue number1
DOIs
Publication statusPublished - 2017
Externally publishedYes

Bibliographical note

Geen TU Delft-publicatie

Keywords

  • 3D motion analysis
  • Duchenne muscular dystrophy
  • Muscle torque
  • Muscle ultrasound
  • Surface electromyography
  • Upper limb

Fingerprint

Dive into the research topics of 'Dynamic arm study: Quantitative description of upper extremity function and activity of boys and men with duchenne muscular dystrophy'. Together they form a unique fingerprint.

Cite this