Effect of partial coherent illumination on Fourier Ptychography

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Fourier Ptychography is a computational imaging technique able to decouple high resolution from wide field of view, bypassing the diffraction limit of the microscope. Since it does not rely on high precision mechanics or fluorescent imaging, it is of practical interest for implementation in low scale devices. Despite its gains, realizing a functional low-cost setup working at the theoretical limits is challenging due to many factors causing discrepancies between theory and practice. Misalignment of the light emitting diode array (LED-array), optical system aberrations and use of partial coherent sources are common issues which have been addressed with calibration algorithms. However, physical interpretation of how these factors influence the algorithm and cause mismatches between theory and practice has had little attention so far. This work provides a discussion based on simulation results on the effect of the partial coherence of the source. From obtained results, an optimal set of LEDs for data acquisition is described which avoids degeneracy caused by partial coherence and is based on the numerical aperture (NA) of the objective and source parameters such as bandwidth and size.
Original languageEnglish
Title of host publicationProceedings of SPIE
Subtitle of host publicationLabel-Free Biomedical Imaging and Sensing (LBIS) 2020
EditorsNatan T. Shaked, Oliver Hayden
Place of PublicationBellingham, WA, USA
Number of pages7
ISBN (Electronic)9781510632653
ISBN (Print)978-1-5106-3265-3
Publication statusPublished - 2020
EventSPIE BiOS 2020: Label-free Biomedical Imaging and Sensing (LBIS) 2020 - San Francisco, United States
Duration: 1 Feb 20206 Feb 2020

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceSPIE BiOS 2020: Label-free Biomedical Imaging and Sensing (LBIS) 2020
Country/TerritoryUnited States
CitySan Francisco


  • Fourier Ptychography
  • Partial Coherence
  • Coherence
  • Physical Optics


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