TY - JOUR
T1 - Effects of bone substitute architecture and surface properties on cell response, angiogenesis, and structure of new bone
AU - Bobbert, Francoise
AU - Zadpoor, Amir
PY - 2017
Y1 - 2017
N2 - The success of bone substitutes used to repair bone defects such as critical sized defects depends on the architecture of the porous biomaterial. The architectural parameters and surface properties affect cell seeding efficiency, cell response, angiogenesis, and eventually bone formation. The relevant parameters include pore size and porosity, pore shape and fibre orientation, surface properties, and mechanical properties. For example, small pores are preferable for cell seeding, but limit cell viability, cell proliferation and differentiation. Moreover, the pore size and geometry affect the alignment of cells and the structure of the regenerated bone. This paper presents an overview of the effects of porous biomaterial architecture including pore size and porosity, pore shape and fibre orientation, surface topography and chemistry, and structure stiffness on cell seeding efficiency, cell response, angiogenesis, and bone formation.
AB - The success of bone substitutes used to repair bone defects such as critical sized defects depends on the architecture of the porous biomaterial. The architectural parameters and surface properties affect cell seeding efficiency, cell response, angiogenesis, and eventually bone formation. The relevant parameters include pore size and porosity, pore shape and fibre orientation, surface properties, and mechanical properties. For example, small pores are preferable for cell seeding, but limit cell viability, cell proliferation and differentiation. Moreover, the pore size and geometry affect the alignment of cells and the structure of the regenerated bone. This paper presents an overview of the effects of porous biomaterial architecture including pore size and porosity, pore shape and fibre orientation, surface topography and chemistry, and structure stiffness on cell seeding efficiency, cell response, angiogenesis, and bone formation.
UR - http://resolver.tudelft.nl/uuid:ddfe660d-9728-4be5-83ee-4ef1e44fd840
U2 - 10.1039/C7TB00741H
DO - 10.1039/C7TB00741H
M3 - Article
SN - 2050-750X
VL - 5
SP - 6175
EP - 6192
JO - Journal of Materials Chemistry B
JF - Journal of Materials Chemistry B
IS - 31
ER -