Efficient and Practical Transfer Hydrogenation of Ketones Catalyzed by a Simple Bidentate Mn−NHC Complex

Robbert van Putten, Joeri Benschop, Vincent J. de Munck, Manuela Weber, Christian Müller, Georgy A. Filonenko, Evgeny A. Pidko

Research output: Contribution to journalArticleScientificpeer-review

9 Citations (Scopus)
4 Downloads (Pure)

Abstract

Catalytic reductions of carbonyl-containing compounds are highly important for the safe, sustainable, and economical production of alcohols. Herein, we report on the efficient transfer hydrogenation of ketones catalyzed by a highly potent Mn(I)−NHC complex. Mn−NHC 1 is practical at metal concentrations as low as 75 ppm, thus approaching loadings more conventionally reserved for noble metal based systems. With these low Mn concentrations, catalyst deactivation is found to be highly temperature dependent and becomes especially prominent at increased reaction temperature. Ultimately, understanding of deactivation pathways could help close the activity/stability-gap with Ru and Ir catalysts towards the practical implementation of sustainable earth-abundant Mn-complexes.

Original languageEnglish
Number of pages4
JournalChemCatChem
Volume11
Issue number21
DOIs
Publication statusPublished - 2019

Keywords

  • Alcohols
  • Ketones
  • Manganese
  • N-Heterocyclic Carbene
  • Transfer Hydrogenation

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