Electric field focusing and shifting technique in deep brain stimulation using a dynamic tripolar current source

Virgilio Valente, Andreas Demosthenous, Richard Bayford

Research output: Chapter in Book/Conference proceedings/Edited volumeConference contributionScientificpeer-review

4 Citations (Scopus)

Abstract

Deep brain stimulation (DBS) is a widely accepted clinical tool adopted for the treatment of a number of motor disorders. Despite its clinical efficacy, its underlying mechanisms have not been yet fully understood. One major issue that we identify as partly responsible for this lack of understanding is related to the poor control over the size, shape and location of the distribution of the depolarizing field around the electrode. With this and a parallel work the authors are proposing to develop and implement techniques that would allow for some degree of control over the distribution of the potential fields. This paper presents the application to DBS of a technique based on a tripolar current source configuration, with adjustable current flow through the lateral (anodic) branches of the tripole. The behavior of potential fields in the tissue were simulated by adopting FEM models of DBS electrode implanted in brain tissue. The profiles of simulated and measured fields were in agreement and they have shown how a dynamic tripolar current source can be adopted to obtain increase the focus and control the location of distribution of the fields around the electrode.

Original languageEnglish
Title of host publicationISCAS 2010 - 2010 IEEE International Symposium on Circuits and Systems
Subtitle of host publicationNano-Bio Circuit Fabrics and Systems
Pages2091-2094
Number of pages4
DOIs
Publication statusPublished - 31 Aug 2010
Externally publishedYes
Event2010 IEEE International Symposium on Circuits and Systems: Nano-Bio Circuit Fabrics and Systems, ISCAS 2010 - Paris, France
Duration: 30 May 20102 Jun 2010

Publication series

NameISCAS 2010 - 2010 IEEE International Symposium on Circuits and Systems: Nano-Bio Circuit Fabrics and Systems

Conference

Conference2010 IEEE International Symposium on Circuits and Systems: Nano-Bio Circuit Fabrics and Systems, ISCAS 2010
CountryFrance
CityParis
Period30/05/102/06/10

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