Electrochemical Amplification in Side-by-Side Attoliter Nanogap Transducers

Hamid Reza Zafarani, Klaus Mathwig, Ernst J.R. Sudhölter, Liza Rassaei

Research output: Contribution to journalArticleScientificpeer-review

8 Citations (Scopus)
19 Downloads (Pure)


We report a strategy for the fabrication of a new type of electrochemical nanogap transducer. These nanogap devices are based on signal amplification by redox cycling. Using two steps of electron-beam lithography, vertical gold electrodes are fabricated side by side at a 70 nm distance encompassing a 20 attoliter open nanogap volume. We demonstrate a current amplification factor of 2.5 as well as the possibility to detect the signal of only 60 analyte molecules occupying the detection volume. Experimental voltammetry results are compared to calculations from finite element analysis.

Original languageEnglish
Pages (from-to)724-728
Number of pages5
JournalACS Sensors
Issue number6
Publication statusPublished - 23 Jun 2017


  • electrochemical sensor
  • generator-collector electrodes
  • nanofabrication
  • nanofluidics
  • nanogap sensor
  • redox cycling

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