Abstract
DNA molecules can be concentrated in a narrow region of a nanochannel when driven electrokinetically in submillimolar salt solutions. Transport experiments and theoretical modeling reveal the interplay of electrophoresis, electro-osmosis, and the unique statistical properties of confined polymers that lead to DNA aggregation. A finite conductance through the bulk of the device also plays a crucial role by influencing the electric fields in the nanochannel. We build on this understanding by demonstrating how a nanofluidic device with integrated electrodes can preconcentrate DNA at selected locations and at physiological salt concentrations that are relevant to lab-on-a-chip applications.
| Original language | English |
|---|---|
| Pages (from-to) | 765-772 |
| Number of pages | 8 |
| Journal | Nano Letters: a journal dedicated to nanoscience and nanotechnology |
| Volume | 10 |
| Issue number | 3 |
| Publication status | Published - 2010 |
Keywords
- academic journal papers
- CWTS JFIS >= 2.00