Enantiospecific synthesis of tetrasubstituted δ-lactones

Annabel L. Wilkinson, Ulf Hanefeld, Barrie Wilkinson, Peter F. Leadlay, James Staunton

Research output: Contribution to journalArticleScientificpeer-review

22 Citations (Scopus)

Abstract

For investigations concerning the selectivity of polyketide synthases (PKSs) which have been rationally engineered through genetic techniques the synthesis of substituted δ-lactones is of great importance. An enantiospecific route towards eight of the possible sixteen stereoisomers was developed which is also readily adaptable for the introduction of alkyl modifications and isotopic labels.

Original languageEnglish
Pages (from-to)9827-9830
JournalTetrahedron Letters
Volume39
Issue number52
DOIs
Publication statusPublished - 1998
Externally publishedYes

Keywords

  • Aldol reaction
  • Asymmetric synthesis
  • Combinatorial Biosynthesis
  • Lactones
  • Polyketides

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