Enhancing Magnetic Hyperthermia Efficiency in Pd/Fe-Oxide Hybrid Nanoparticles through Mn-Doping

A. Maier, Q. Jia, K.J. Shukla, A.I. Dugulan, P.L. Hagedoorn, R. van Oossanen, G.C. van Rhoon, A.G. Denkova, K. Djanashvili*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Multifunctional, biocompatible magnetic materials, such as iron oxide nanoparticles (IONPs), hold great potential for biomedical applications including diagnostics (e.g., MRI) and cancer therapy. In particular, they can play a crucial role in advancing cancer thermotherapy by generating heat when administered intratumorally and when exposed to an alternating magnetic field. This heat application is often combined with radio- (chemo)therapy and/or imaging. Consequently, the design of materials for such a multimodal approach requires hybrid nanoparticles that retain their magnetic properties while integrating additional functionalities. This work introduces synthesis and investigation of magnetically enhanced nanoparticles with a palladium core (envisioned for future radiolabeling with therapeutic 103Pd) and a magnetic iron oxide shell containing paramagnetic manganese (Pd/Fe|(nMn)-oxide, n = 0.25 and 0.5). Doping the iron oxide lattice with Mn significantly increases magnetic saturation, boosting specific loss power up to 1.7 times compared to that of undoped analogs. Interestingly, higher Mn-content in Pd/Fe|(0.5Mn)-oxide leads to a pronounced Mn outer rim, enhancing the heating efficiency at 346 kHz and 23 mT and contributing to the water exchange on the surface of the paramagnetically doped nanoparticles, resulting in additional T1 MRI contrast. The enhanced magnetic properties of the hybrid Pd/Fe|Mn-oxide nanoparticles enable effective therapeutic outcomes with injection of only small quantities of the material, offering great potential for effective cancer treatment strategies that combine hyperthermia/thermal ablation with radiotherapy while allowing for real-time monitoring via MRI.
Original languageEnglish
Pages (from-to)27465-27475
Number of pages11
JournalACS Applied Nano Materials
Volume23
Issue number7
DOIs
Publication statusPublished - 2024

Keywords

  • hybrid nanoparticles
  • palladium
  • iron oxide
  • manganese doping
  • magnetic properties
  • hyperthermia/thermal ablation
  • MRI contrast

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