Euler-Lagrange analysis towards representative down-scaling of a 22 m3 aerobic S. cerevisiae fermentation

Cees Haringa; Amit T. Deshmukh; Rob Mudde; Henk Noorman

doi:10.1016/j.ces.2017.01.014

Euler-Lagrange analysis towards representative down-scaling of a 22 m3 aerobic S. cerevisiae fermentation

Cees Haringa, Amit T. Deshmukh, Rob Mudde, Henk Noorman

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Abstract

With reaction timescales equal to or shorter than the circulation time, the ideal mixing assumption typically does not hold for large scale bioreactors. As a consequence large scale gradients in extra-cellular conditions such as the substrate concentration exist, which may significantly impact the metabolism of micro-organisms and thereby the process performance. The influence of extra-cellular variations on the organism can be tested using so-called scale-down simulators, laboratory scale setups where deliberate, controlled fluctuations are imposed in the extra-cellular environment.

Original language	English
Pages (from-to)	653-669
Number of pages	17
Journal	Chemical Engineering Science
Volume	170
Early online date	23 Jan 2017
DOIs	https://doi.org/10.1016/j.ces.2017.01.014
Publication status	Published - 12 Oct 2017

Keywords

Industrial scale
Euler-Lagrange
CFD
Scale-down
Fermentation

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10.1016/j.ces.2017.01.014

1-s2.0-S0009250917300337-mainFinal published version, 4.14 MBLicence: CC BY

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Euler-Lagrange analysis towards representative down-scaling of a 22 m3 aerobic S. cerevisiae fermentation

Abstract

Keywords

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Through the Organism’s eyes: The interaction between hydrodynamics and metabolic dynamics in industrial-scale fermentation processes

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