Euler-Lagrange analysis towards representative down-scaling of a 22 m3 aerobic S. cerevisiae fermentation

Cees Haringa, Amit T. Deshmukh, Rob Mudde, Henk Noorman

Research output: Contribution to journalArticleScientificpeer-review

31 Citations (Scopus)
129 Downloads (Pure)

Abstract

With reaction timescales equal to or shorter than the circulation time, the ideal mixing assumption typically does not hold for large scale bioreactors. As a consequence large scale gradients in extra-cellular conditions such as the substrate concentration exist, which may significantly impact the metabolism of micro-organisms and thereby the process performance. The influence of extra-cellular variations on the organism can be tested using so-called scale-down simulators, laboratory scale setups where deliberate, controlled fluctuations are imposed in the extra-cellular environment.
Original languageEnglish
Pages (from-to)653-669
Number of pages17
JournalChemical Engineering Science
Volume170
Early online date23 Jan 2017
DOIs
Publication statusPublished - 12 Oct 2017

Keywords

  • Industrial scale
  • Euler-Lagrange
  • CFD
  • Scale-down
  • Fermentation

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