Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA

Dousatsu Sakata, Nathanael Lampe, Mathieu Karamitros, Ioanna Kyriakou, Oleg Belov, Mario A. Bernal, David Bolst, Marie Claude Bordage, Jeremy M.C. Brown, More Authors

Research output: Contribution to journalArticleScientificpeer-review

19 Citations (Scopus)

Abstract

The advancement of multidisciplinary research fields dealing with ionising radiation induced biological damage – radiobiology, radiation physics, radiation protection and, in particular, medical physics – requires a clear mechanistic understanding of how cellular damage is induced by ionising radiation. Monte Carlo (MC) simulations provide a promising approach for the mechanistic simulation of radiation transport and radiation chemistry, towards the in silico simulation of early biological damage. We have recently developed a fully integrated MC simulation that calculates early single strand breaks (SSBs) and double strand breaks (DSBs) in a fractal chromatin based human cell nucleus model. The results of this simulation are almost equivalent to past MC simulations when considering direct/indirect strand break fraction, DSB yields and fragment distribution. The simulation results agree with experimental data on DSB yields within 13.6% on average and fragment distributions agree within an average of 34.8%.

Original languageEnglish
Pages (from-to)152-157
JournalPhysica Medica
Volume62
DOIs
Publication statusPublished - 2019

Keywords

  • DNA damage
  • Geant4-DNA
  • Monte Carlo simulation

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