Evaluation of the Pharmacokinetics and dosimetry of 225Ac Alpha Radionuclide Carriers

Jasper Kouwenberg, Bert Wolterbeek, Antonia Denkova

Research output: Chapter in Book/Conference proceedings/Edited volumeChapterScientific

Abstract

Introduction: The use of 225Ac for alpha radionuclide therapy is a relatively novel approach, where the dense energy deposition of alpha radiation is used to treat cancer more effectively. 225Ac has, compared to conventional radionuclides, a long half-life of 10 days and a long decay chain, yielding 4 alpha particles, 2 beta particles and several gamma rays. This long decay chain presents new challenges. Daughter radionuclides that separate from the radionuclide carrier during radioactive decay can end up freely circulating …
Original languageEnglish
Title of host publicationFluorescent Nuclear Track Detectors for Alpha Particle Measurement
EditorsJ.J. Kouwenberg
Pages138-180
ISBN (Electronic)978-94-6186-911-1
Publication statusPublished - 2018

Publication series

NameFluorescent Nuclear Track Detectors for alpha Particle Measurement

Fingerprint Dive into the research topics of 'Evaluation of the Pharmacokinetics and dosimetry of 225Ac Alpha Radionuclide Carriers'. Together they form a unique fingerprint.

Cite this