Evolutionary dynamics in the fungal polarization network, a mechanistic perspective

Eveline T. Diepeveen, L.M. Iñigo De La Cruz, Liedewij Laan

Research output: Contribution to journalReview articleScientificpeer-review

1 Citation (Scopus)
27 Downloads (Pure)

Abstract

Polarity establishment underlies proper cell cycle completion across virtually all organisms. Much progress has been made in generating an understanding of the structural and functional components of this process, especially in model species. Here we focus on the evolutionary dynamics of the fungal polarization protein network in order to determine general components and mechanistic principles, species- or lineage-specific adaptations and the evolvability of the network. The currently available genomic and proteomic screens in a variety of fungal species have shown three main characteristics: (1) certain proteins, processes and functions are conserved throughout the fungal clade; (2) orthologous functions can never be assumed, as various cases have been observed of homologous loci with dissimilar functions; (3) species have, typically, various species- or lineage-specific proteins incorporated in their polarization network. Further large-scale comparative and experimental studies, including those on non-model species representing the great fungal diversity, are needed to gain a better understanding of the evolutionary dynamics and generalities of the polarization network in fungi.

Original languageEnglish
Pages (from-to)375-387
Number of pages13
JournalBiophysical Reviews
Volume9
Issue number4
DOIs
Publication statusPublished - 1 Aug 2017

Keywords

  • Adaptation
  • Cell polarity
  • Evolution
  • Evolutionary conservation
  • Fungi
  • Protein network

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