Expanding the Spectrum of Light-Driven Peroxygenase Reactions

Sébastien J.P. Willot; Elena Fernández-Fueyo; Florian Tieves; Milja Pesic; Miguel Alcalde; Isabel W.C.E. Arends; Chan Beum Park; Frank Hollmann

doi:10.1021/acscatal.8b03752

Expanding the Spectrum of Light-Driven Peroxygenase Reactions

Sébastien J.P. Willot, Elena Fernández-Fueyo, Florian Tieves, Milja Pesic, Miguel Alcalde, Isabel W.C.E. Arends, Chan Beum Park, Frank Hollmann^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

Peroxygenases require a controlled supply of H₂O₂ to operate efficiently. Here, we propose a photocatalytic system for the reductive activation of ambient O₂ to produce H₂O₂ which uses the energy provided by visible light more efficiently based on the combination of wavelength-complementary photosensitizers. This approach was coupled to an enzymatic system to make formate available as a sacrificial electron donor. The scope and current limitations of this approach are reported and discussed.

Original language	English
Pages (from-to)	890-894
Journal	ACS Catalysis
Volume	9
Issue number	2
DOIs	https://doi.org/10.1021/acscatal.8b03752
Publication status	Published - 2019

Keywords

biocatalysis
formate dehydrogenase
hydrogen peroxide formation
oxyfunctionalization
peroxygenases
photocatalysis

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10.1021/acscatal.8b03752

acscatal.8b03752Final published version, 1.23 MBLicence: CC BY

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title = "Expanding the Spectrum of Light-Driven Peroxygenase Reactions",

abstract = "Peroxygenases require a controlled supply of H2O2 to operate efficiently. Here, we propose a photocatalytic system for the reductive activation of ambient O2 to produce H2O2 which uses the energy provided by visible light more efficiently based on the combination of wavelength-complementary photosensitizers. This approach was coupled to an enzymatic system to make formate available as a sacrificial electron donor. The scope and current limitations of this approach are reported and discussed.",

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T1 - Expanding the Spectrum of Light-Driven Peroxygenase Reactions

AU - Willot, Sébastien J.P.

AU - Fernández-Fueyo, Elena

AU - Tieves, Florian

AU - Pesic, Milja

AU - Alcalde, Miguel

AU - Arends, Isabel W.C.E.

AU - Park, Chan Beum

AU - Hollmann, Frank

PY - 2019

Y1 - 2019

N2 - Peroxygenases require a controlled supply of H2O2 to operate efficiently. Here, we propose a photocatalytic system for the reductive activation of ambient O2 to produce H2O2 which uses the energy provided by visible light more efficiently based on the combination of wavelength-complementary photosensitizers. This approach was coupled to an enzymatic system to make formate available as a sacrificial electron donor. The scope and current limitations of this approach are reported and discussed.

AB - Peroxygenases require a controlled supply of H2O2 to operate efficiently. Here, we propose a photocatalytic system for the reductive activation of ambient O2 to produce H2O2 which uses the energy provided by visible light more efficiently based on the combination of wavelength-complementary photosensitizers. This approach was coupled to an enzymatic system to make formate available as a sacrificial electron donor. The scope and current limitations of this approach are reported and discussed.

KW - biocatalysis

KW - formate dehydrogenase

KW - hydrogen peroxide formation

KW - oxyfunctionalization

KW - peroxygenases

KW - photocatalysis

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M3 - Article

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VL - 9

SP - 890

EP - 894

JO - ACS Catalysis

JF - ACS Catalysis

IS - 2

ER -

Expanding the Spectrum of Light-Driven Peroxygenase Reactions

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