Expanding the Spectrum of Light-Driven Peroxygenase Reactions

Sébastien J.P. Willot; Elena Fernández-Fueyo; Florian Tieves; Milja Pesic; Miguel Alcalde; Isabel W.C.E. Arends; Chan Beum Park; Frank Hollmann

doi:10.1021/acscatal.8b03752

Expanding the Spectrum of Light-Driven Peroxygenase Reactions

Sébastien J.P. Willot
, Elena Fernández-Fueyo
, Florian Tieves
, Milja Pesic
, Miguel Alcalde
, Isabel W.C.E. Arends
, Chan Beum Park
, Frank Hollmann^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

76 Citations (Scopus)

255 Downloads (Pure)

Abstract

Peroxygenases require a controlled supply of H₂O₂ to operate efficiently. Here, we propose a photocatalytic system for the reductive activation of ambient O₂ to produce H₂O₂ which uses the energy provided by visible light more efficiently based on the combination of wavelength-complementary photosensitizers. This approach was coupled to an enzymatic system to make formate available as a sacrificial electron donor. The scope and current limitations of this approach are reported and discussed.

Original language	English
Pages (from-to)	890-894
Journal	ACS Catalysis
Volume	9
Issue number	2
DOIs	https://doi.org/10.1021/acscatal.8b03752
Publication status	Published - 2019

Keywords

biocatalysis
formate dehydrogenase
hydrogen peroxide formation
oxyfunctionalization
peroxygenases
photocatalysis

Access to Document

10.1021/acscatal.8b03752

acscatal.8b03752Final published version, 1.23 MBLicence: CC BY

Cite this

@article{4e2e518602a14888a031b03efbacc454,

title = "Expanding the Spectrum of Light-Driven Peroxygenase Reactions",

abstract = "Peroxygenases require a controlled supply of H2O2 to operate efficiently. Here, we propose a photocatalytic system for the reductive activation of ambient O2 to produce H2O2 which uses the energy provided by visible light more efficiently based on the combination of wavelength-complementary photosensitizers. This approach was coupled to an enzymatic system to make formate available as a sacrificial electron donor. The scope and current limitations of this approach are reported and discussed.",

keywords = "biocatalysis, formate dehydrogenase, hydrogen peroxide formation, oxyfunctionalization, peroxygenases, photocatalysis",

author = "Willot, \{S{\'e}bastien J.P.\} and Elena Fern{\'a}ndez-Fueyo and Florian Tieves and Milja Pesic and Miguel Alcalde and Arends, \{Isabel W.C.E.\} and Park, \{Chan Beum\} and Frank Hollmann",

year = "2019",

doi = "10.1021/acscatal.8b03752",

language = "English",

volume = "9",

pages = "890--894",

journal = "ACS Catalysis",

issn = "2155-5435",

publisher = "American Chemical Society (ACS)",

number = "2",

}

TY - JOUR

T1 - Expanding the Spectrum of Light-Driven Peroxygenase Reactions

AU - Willot, Sébastien J.P.

AU - Fernández-Fueyo, Elena

AU - Tieves, Florian

AU - Pesic, Milja

AU - Alcalde, Miguel

AU - Arends, Isabel W.C.E.

AU - Park, Chan Beum

AU - Hollmann, Frank

PY - 2019

Y1 - 2019

N2 - Peroxygenases require a controlled supply of H2O2 to operate efficiently. Here, we propose a photocatalytic system for the reductive activation of ambient O2 to produce H2O2 which uses the energy provided by visible light more efficiently based on the combination of wavelength-complementary photosensitizers. This approach was coupled to an enzymatic system to make formate available as a sacrificial electron donor. The scope and current limitations of this approach are reported and discussed.

AB - Peroxygenases require a controlled supply of H2O2 to operate efficiently. Here, we propose a photocatalytic system for the reductive activation of ambient O2 to produce H2O2 which uses the energy provided by visible light more efficiently based on the combination of wavelength-complementary photosensitizers. This approach was coupled to an enzymatic system to make formate available as a sacrificial electron donor. The scope and current limitations of this approach are reported and discussed.

KW - biocatalysis

KW - formate dehydrogenase

KW - hydrogen peroxide formation

KW - oxyfunctionalization

KW - peroxygenases

KW - photocatalysis

UR - https://www.scopus.com/pages/publications/85060038413

U2 - 10.1021/acscatal.8b03752

DO - 10.1021/acscatal.8b03752

M3 - Article

AN - SCOPUS:85060038413

SN - 2155-5435

VL - 9

SP - 890

EP - 894

JO - ACS Catalysis

JF - ACS Catalysis

IS - 2

ER -

Expanding the Spectrum of Light-Driven Peroxygenase Reactions

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this