FOx News: Towards Methanol-driven Biocatalytic Oxyfunctionalisation Reactions

Sébastien J.P. Willot, Manh Dat Hoang, Caroline E. Paul, Miguel Alcalde, Isabel W.C.E. Arends, Andreas S. Bommarius, Bettina Bommarius, Frank Hollmann*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

8 Citations (Scopus)
36 Downloads (Pure)


The novel formate oxidase from Aspergillus oryzae (AoFOx) is a useful catalyst to promote H2O2-dependent oxyfunctionalisation reactions. In this contribution we exploit the substrate promiscuity of AoFOx to fully oxidise methanol and formaldehyde to CO2 and drive peroxygenase-catalysed stereoselective oxyfunctionalisation reactions. The highly atom efficient H2O2 generation system also enabled high catalytic turnover of the peroxygenase production enzyme.

Original languageEnglish
Pages (from-to)2713-2716
Number of pages5
Issue number10
Publication statusPublished - 2020


  • Biocatalysis
  • Formate oxidase
  • Methanol
  • Oxyfunctionalisation
  • Peroxygenases


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