Genome-wide coexpression of steroid receptors in the mouse brain: identifying signaling pathways and functionally coordinated regions

Ahmed Mahfouz; Boudewijn Lelieveldt; Aldo Grefhorst; Isabel M. Mol; Hetty C.M. Sips; José K. van den Heuvel; Jenny A. Visser; Marcel Reinders; Onno C. Meijer; null More Authors

Genome-wide coexpression of steroid receptors in the mouse brain: identifying signaling pathways and functionally coordinated regions

Ahmed Mahfouz, Boudewijn Lelieveldt, Aldo Grefhorst, Isabel M. Mol, Hetty C.M. Sips, José K. van den Heuvel, Jenny A. Visser, Marcel Reinders, Onno C. Meijer, More Authors

Pattern Recognition and Bioinformatics

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Abstract

Steroid hormones coordinate the activity of many brain regions by binding to nuclear receptors that act as transcription factors. This study uses genome-wide correlation of gene expression in the mouse brain to discover (i) brain regions that respond in a similar manner to particular steroids, (ii) signaling pathways that are used in a steroid receptor and brain region-specific manner, and (iii) potential target genes and relationships between groups of target genes. The data constitute a rich repository for the research community to support further new insights in neuroendocrine relationships and to develop novel ways to manipulate brain activity in research or clinical settings.

Original language	English
Pages	1
Number of pages	1
Publication status	Published - 2015

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title = "Genome-wide coexpression of steroid receptors in the mouse brain: identifying signaling pathways and functionally coordinated regions",

abstract = "Steroid hormones coordinate the activity of many brain regions by binding to nuclear receptors that act as transcription factors. This study uses genome-wide correlation of gene expression in the mouse brain to discover (i) brain regions that respond in a similar manner to particular steroids, (ii) signaling pathways that are used in a steroid receptor and brain region-specific manner, and (iii) potential target genes and relationships between groups of target genes. The data constitute a rich repository for the research community to support further new insights in neuroendocrine relationships and to develop novel ways to manipulate brain activity in research or clinical settings.",

author = "Ahmed Mahfouz and Boudewijn Lelieveldt and Aldo Grefhorst and Mol, {Isabel M.} and Sips, {Hetty C.M.} and {van den Heuvel}, {Jos{\'e} K.} and Visser, {Jenny A.} and Marcel Reinders and Meijer, {Onno C.} and {More Authors}",

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T1 - Genome-wide coexpression of steroid receptors in the mouse brain: identifying signaling pathways and functionally coordinated regions

AU - Mahfouz, Ahmed

AU - Lelieveldt, Boudewijn

AU - Grefhorst, Aldo

AU - Mol, Isabel M.

AU - Sips, Hetty C.M.

AU - van den Heuvel, José K.

AU - Visser, Jenny A.

AU - Reinders, Marcel

AU - Meijer, Onno C.

AU - More Authors, null

PY - 2015

Y1 - 2015

N2 - Steroid hormones coordinate the activity of many brain regions by binding to nuclear receptors that act as transcription factors. This study uses genome-wide correlation of gene expression in the mouse brain to discover (i) brain regions that respond in a similar manner to particular steroids, (ii) signaling pathways that are used in a steroid receptor and brain region-specific manner, and (iii) potential target genes and relationships between groups of target genes. The data constitute a rich repository for the research community to support further new insights in neuroendocrine relationships and to develop novel ways to manipulate brain activity in research or clinical settings.

AB - Steroid hormones coordinate the activity of many brain regions by binding to nuclear receptors that act as transcription factors. This study uses genome-wide correlation of gene expression in the mouse brain to discover (i) brain regions that respond in a similar manner to particular steroids, (ii) signaling pathways that are used in a steroid receptor and brain region-specific manner, and (iii) potential target genes and relationships between groups of target genes. The data constitute a rich repository for the research community to support further new insights in neuroendocrine relationships and to develop novel ways to manipulate brain activity in research or clinical settings.

UR - http://bioinformatics.ewi.tudelft.nl/sites/default/files/ahmedmafouz-december-2015.pdf

M3 - Poster

SP - 1

ER -

Genome-wide coexpression of steroid receptors in the mouse brain: identifying signaling pathways and functionally coordinated regions

Abstract

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