Genome-wide coexpression of steroid receptors in the mouse brain: identifying signaling pathways and functionally coordinated regions

Ahmed Mahfouz, Boudewijn Lelieveldt, Aldo Grefhorst, Isabel M. Mol, Hetty C.M. Sips, José K. van den Heuvel, Jenny A. Visser, Marcel Reinders, Onno C. Meijer, More Authors

Research output: Contribution to conferencePosterScientific

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Abstract

Steroid hormones coordinate the activity of many brain regions by binding to nuclear receptors that act as transcription factors. This study uses genome-wide correlation of gene expression in the mouse brain to discover (i) brain regions that respond in a similar manner to particular steroids, (ii) signaling pathways that are used in a steroid receptor and brain region-specific manner, and (iii) potential target genes and relationships between groups of target genes. The data constitute a rich repository for the research community to support further new insights in neuroendocrine relationships and to develop novel ways to manipulate brain activity in research or clinical settings.
Original languageEnglish
Pages1
Number of pages1
Publication statusPublished - 2015

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    Mahfouz, A., Lelieveldt, B., Grefhorst, A., Mol, I. M., Sips, H. C. M., van den Heuvel, J. K., Visser, J. A., Reinders, M., Meijer, O. C., & More Authors (2015). Genome-wide coexpression of steroid receptors in the mouse brain: identifying signaling pathways and functionally coordinated regions. 1.