Steroid hormones coordinate the activity of many brain regions by binding to nuclear receptors that act as transcription factors. This study uses genome-wide correlation of gene expression in the mouse brain to discover (i) brain regions that respond in a similar manner to particular steroids, (ii) signaling pathways that are used in a steroid receptor and brain region-specific manner, and (iii) potential target genes and relationships between groups of target genes. The data constitute a rich repository for the research community to support further new insights in neuroendocrine relationships and to develop novel ways to manipulate brain activity in research or clinical settings.
|Number of pages||1|
|Publication status||Published - 2015|
Mahfouz, A., Lelieveldt, B., Grefhorst, A., Mol, I. M., Sips, H. C. M., van den Heuvel, J. K., Visser, J. A., Reinders, M., Meijer, O. C., & More Authors (2015). Genome-wide coexpression of steroid receptors in the mouse brain: identifying signaling pathways and functionally coordinated regions. 1.