Grand Research Challenges for Sustainable Industrial Biotechnology

Adrie J.J. Straathof; S. Aljoscha Wahl; Kirsten R. Benjamin; Ralf Takors; Nick Wierckx; Henk J. Noorman

doi:10.1016/j.tibtech.2019.04.002

Grand Research Challenges for Sustainable Industrial Biotechnology

Adrie J.J. Straathof^*, S. Aljoscha Wahl, Kirsten R. Benjamin, Ralf Takors, Nick Wierckx, Henk J. Noorman

^*Corresponding author for this work

BT/Bioprocess Engineering

Research output: Contribution to journal › Review article › peer-review

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Abstract

Future manufacturing will focus on new, improved products as well as on new and enhanced production methods. Recent biotechnological and scientific advances, such as CRISPR/Cas and various omic technologies, pave the way to exciting novel biotechnological research, development, and commercialization of new sustainable products. Rigorous mathematical descriptions of microbial cells and consortia thereof will enable deeper biological understanding and lead to powerful in silico cellular models. Biological engineering, namely model-based design together with synthetic biology, will accelerate the construction of robust and high-performing microorganisms. Using these organisms, and ambitions towards zero-concepts with respect to emissions and excess resources in bioprocess engineering, industrial biotechnology is expected to become highly integrated into sustainable generations of technology systems.

Original language	English
Pages (from-to)	1042-1050
Number of pages	9
Journal	Trends in Biotechnology
Volume	37
Issue number	10
DOIs	https://doi.org/10.1016/j.tibtech.2019.04.002
Publication status	Published - 2019

Bibliographical note

Accepted Author Manuscript

Keywords

bio-based production
biological engineering
bioprocess engineering
industrial fermentation
systems biotechnology

Access to Document

10.1016/j.tibtech.2019.04.002

Straathof_Opinion_manuscript_Trends_in_Biotechnology_2019_Author_s_versionAccepted author manuscript, 820 KB

Cite this

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title = "Grand Research Challenges for Sustainable Industrial Biotechnology",

abstract = "Future manufacturing will focus on new, improved products as well as on new and enhanced production methods. Recent biotechnological and scientific advances, such as CRISPR/Cas and various omic technologies, pave the way to exciting novel biotechnological research, development, and commercialization of new sustainable products. Rigorous mathematical descriptions of microbial cells and consortia thereof will enable deeper biological understanding and lead to powerful in silico cellular models. Biological engineering, namely model-based design together with synthetic biology, will accelerate the construction of robust and high-performing microorganisms. Using these organisms, and ambitions towards zero-concepts with respect to emissions and excess resources in bioprocess engineering, industrial biotechnology is expected to become highly integrated into sustainable generations of technology systems.",

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AU - Straathof, Adrie J.J.

AU - Wahl, S. Aljoscha

AU - Benjamin, Kirsten R.

AU - Takors, Ralf

AU - Wierckx, Nick

AU - Noorman, Henk J.

N1 - Accepted Author Manuscript

PY - 2019

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N2 - Future manufacturing will focus on new, improved products as well as on new and enhanced production methods. Recent biotechnological and scientific advances, such as CRISPR/Cas and various omic technologies, pave the way to exciting novel biotechnological research, development, and commercialization of new sustainable products. Rigorous mathematical descriptions of microbial cells and consortia thereof will enable deeper biological understanding and lead to powerful in silico cellular models. Biological engineering, namely model-based design together with synthetic biology, will accelerate the construction of robust and high-performing microorganisms. Using these organisms, and ambitions towards zero-concepts with respect to emissions and excess resources in bioprocess engineering, industrial biotechnology is expected to become highly integrated into sustainable generations of technology systems.

AB - Future manufacturing will focus on new, improved products as well as on new and enhanced production methods. Recent biotechnological and scientific advances, such as CRISPR/Cas and various omic technologies, pave the way to exciting novel biotechnological research, development, and commercialization of new sustainable products. Rigorous mathematical descriptions of microbial cells and consortia thereof will enable deeper biological understanding and lead to powerful in silico cellular models. Biological engineering, namely model-based design together with synthetic biology, will accelerate the construction of robust and high-performing microorganisms. Using these organisms, and ambitions towards zero-concepts with respect to emissions and excess resources in bioprocess engineering, industrial biotechnology is expected to become highly integrated into sustainable generations of technology systems.

KW - bio-based production

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Grand Research Challenges for Sustainable Industrial Biotechnology

Abstract

Bibliographical note

Keywords

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