Grand Research Challenges for Sustainable Industrial Biotechnology

Adrie J.J. Straathof*, S. Aljoscha Wahl, Kirsten R. Benjamin, Ralf Takors, Nick Wierckx, Henk J. Noorman

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

96 Citations (Scopus)
778 Downloads (Pure)


Future manufacturing will focus on new, improved products as well as on new and enhanced production methods. Recent biotechnological and scientific advances, such as CRISPR/Cas and various omic technologies, pave the way to exciting novel biotechnological research, development, and commercialization of new sustainable products. Rigorous mathematical descriptions of microbial cells and consortia thereof will enable deeper biological understanding and lead to powerful in silico cellular models. Biological engineering, namely model-based design together with synthetic biology, will accelerate the construction of robust and high-performing microorganisms. Using these organisms, and ambitions towards zero-concepts with respect to emissions and excess resources in bioprocess engineering, industrial biotechnology is expected to become highly integrated into sustainable generations of technology systems.

Original languageEnglish
Pages (from-to)1042-1050
Number of pages9
JournalTrends in Biotechnology
Issue number10
Publication statusPublished - 2019

Bibliographical note

Accepted Author Manuscript


  • bio-based production
  • biological engineering
  • bioprocess engineering
  • industrial fermentation
  • systems biotechnology


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