Gray and white matter volume abnormalities in monozygotic and same-gender dizygotic twins discordant for schizophrenia

H.E. Hulshoff Pol, R.G.H. Brans, N.E.M. Van Haren, H.G. Schnack, M. Langen, W.F.C. Baaré, C.J. Van Oel, R.S. Kahn

Research output: Contribution to journalArticleScientificpeer-review

103 Citations (Scopus)

Abstract

Background Whole brain tissue volume decreases in schizophrenia have been related to both genetic risk factors and disease-related (possibly nongenetic) factors; however, whether genetic and environmental risk factors in the brains of patients with schizophrenia are differentially reflected in gray or white matter volume change is not known. Methods Magnetic resonance imaging (1.5 T) brain scans of 11 monozygotic and 11 same-gender dizygotic twin pairs discordant for schizophrenia were acquired and compared with 11 monozygotic and 11 same-gender dizygotic healthy control twin pairs. Results Repeated-measures volume analysis of covariance revealed decreased whole brain volume in the patients with schizophrenia as compared with their co-twins and with healthy twin pairs. Decreased white matter volume was found in discordant twin pairs compared with healthy twin pairs, particularly in the monozygotic twin pairs. A decrease in gray matter was found in the patients compared with their co-twins and compared with the healthy twins. Conclusions The results suggest that the decreases in white matter volume reflect the increased genetic risk to develop schizophrenia, whereas the decreases in gray matter volume are related to environmental risk factors. Study of genes involved in the (maintenance) of white matter structures may be particularly fruitful in schizophrenia.
Original languageEnglish
Pages (from-to)126-130
Number of pages5
JournalBiological Psychiatry
Volume55
Issue number2
DOIs
Publication statusPublished - 2004

Keywords

  • Genetic risk
  • Gray matter
  • Magnetic resonance imaging
  • Morphology
  • Schizophrenia
  • Twins
  • White matter

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