Abstract
The increasing role of biocatalysis in the green and sustainable manufacture of chemicals is discussed. In the last two decades the breadth and scope of biocatalysis has increased enormously as a result of remarkable advances in metagenomics, protein engineering and bioinformatics. Moreover, the use of enzymes has become more cost-effective through advances in immobilization technologies and the application of the immobilized enzymes in continuous flow operation in packed bed reactors. Consequently, biocatalysis is already the method of choice for the synthesis of enantiopure chiral products for the pharmaceutical and fine chemical industries. Further applications in commodity chemicals manufacture are currently being stimulated by the increasing maturity of biocatalysis and the ongoing transition to a bio-based circular economy based on the valorization of organic waste on the road to net zero manufacturing.
| Original language | English |
|---|---|
| Article number | 114571 |
| Number of pages | 11 |
| Journal | Catalysis Today |
| Volume | 431 |
| DOIs | |
| Publication status | Published - 2024 |
Bibliographical note
Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-careOtherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.
Keywords
- Bio-based economy
- Biocatalysis
- Biocatalysis in flow
- Biocatalytic cascades
- Directed evolution
- Enzyme immobilization
- Sustainability
- Waste valorization
