Halofunctionalization of alkenes by vanadium chloroperoxidase from Curvularia inaequalis

Jia Jia Dong, Elena Fernandez Fueyo, Jingbo Li, Zheng Guo, Rokus Renirie, Ron Wever, Frank Hollmann

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Abstract

The vanadium-dependent chloroperoxidase from Curvularia inaequalis is a stable and efficient biocatalyst for the hydroxyhalogenation of a broad range of alkenes into halohydrins. Up to 1 200 000 TON with 69 s−1 TOF were observed for the biocatalyst. A bienzymatic cascade to yield epoxides as reaction products is presented.
Original languageEnglish
Number of pages4
JournalChemical Communications
Volume53
Issue number46
DOIs
Publication statusPublished - May 2017

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