High Frequency Functional Ultrasound in Mice

S. K.E. Koekkoek, S. Soloukeytbalvandany, B. S. Generowicz, W. S. Vanhoogstraten, N. L. Deoude, H. J. Boele, C. Strydis, G. Leus, C. I. De Zeeuw, More Authors

Research output: Chapter in Book/Conference proceedings/Edited volumeConference contributionScientificpeer-review

3 Citations (Scopus)

Abstract

Functional ultrasound (fUS) is a relatively new imaging modality to study the brain with a high spatiotemporal resolution and a wide field-of-view. In fUS detailed images of cerebral blood flow and volume are used to derive functional information, as changes in local flow and/or volume may reflect neuronal activation through neurovascular coupling. Most fUS studies so far have been performed in rats. Translating fUS to mice, which is a favorable animal model for neuroscience, pleads for a higher spatial resolution than what has been reported so far. As a consequence the temporal sampling of the blood flow should also be increased in order to adequately capture the wide range in blood velocities, as the Doppler shifts are inversely proportional to the spatial resolution. Here we present our first detailed images of the mouse brain vasculature at high spatiotemporal resolution. In addition we show some early experimental work on tracking brain activity upon local electrical stimulation.
Original languageEnglish
Title of host publication2018 IEEE International Ultrasonics Symposium, IUS 2018
EditorsKen-ya Hashimoto , Clemens Ruppel
PublisherIEEE
Number of pages4
Volume2018-October
ISBN (Electronic)978-153863425-7
DOIs
Publication statusPublished - 2018
Event2018 IEEE International Ultrasonics Symposium, IUS 2018 - Portopia Hotel, Kobe, Japan
Duration: 22 Oct 201825 Oct 2018

Conference

Conference2018 IEEE International Ultrasonics Symposium, IUS 2018
Abbreviated titleIUS 2018
CountryJapan
CityKobe
Period22/10/1825/10/18

Keywords

  • fUS
  • high frequency
  • mice brain
  • μDoppler

Fingerprint Dive into the research topics of 'High Frequency Functional Ultrasound in Mice'. Together they form a unique fingerprint.

Cite this