Homeostasis in intestinal organoids at the single cell level

Research output: ThesisDissertation (TU Delft)

19 Downloads (Pure)

Abstract

How does the small intestine maintain itself? What mechanism does it use to achieve
homeostasis, and how optimal is this mechanism? We approached these questions
mainly using cell tracking in organoids, for which we developed new cell trackers.
We found that the intestinal crypt uses a surprisingly simple and effective strategy.
Finally, we showed that cell segmentation and tracking is possible in organoids without fluorescent markers.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Delft University of Technology
Supervisors/Advisors
  • Tans, S.J., Supervisor
  • Ten Wolde, Pieter Rein, Advisor, External person
Award date10 Apr 2024
DOIs
Publication statusPublished - 2024

Keywords

  • organoids
  • small intestine
  • homeostasis
  • cell tracking

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