Horse Liver Alcohol Dehydrogenase-Catalyzed Oxidative Lactamization of Amino Alcohols

Lei Huang; Giovanni Vallian Sayoga; Frank Hollmann; Selin Kara

doi:10.1021/acscatal.8b02355

Horse Liver Alcohol Dehydrogenase-Catalyzed Oxidative Lactamization of Amino Alcohols

Lei Huang, Giovanni Vallian Sayoga, Frank Hollmann, Selin Kara^*

^*Corresponding author for this work

BT/Biocatalysis

Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

A direct synthesis of lactams (5-, 6-, and 7-membered) starting from amino-alcohols in a bienzymatic cascade is reported. Horse liver alcohol dehydrogenase together with the NADH oxidase from Streptococcus mutans were applied for the oxidative lactamization of various amino alcohols. Crucial parameters for the efficiency of this cascade reaction were elucidated. This report represents a direct approach for biocatalytic oxidative lactamization reaction.

Original language	English
Pages (from-to)	8680-8684
Number of pages	5
Journal	ACS Catalysis
Volume	8
Issue number	9
DOIs	https://doi.org/10.1021/acscatal.8b02355
Publication status	Published - 2018

Keywords

cofactor regeneration
enzymatic cascades
horse liver alcohol dehydrogenase
lactams
oxidoreductases

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AU - Huang, Lei

AU - Sayoga, Giovanni Vallian

AU - Hollmann, Frank

AU - Kara, Selin

PY - 2018

Y1 - 2018

N2 - A direct synthesis of lactams (5-, 6-, and 7-membered) starting from amino-alcohols in a bienzymatic cascade is reported. Horse liver alcohol dehydrogenase together with the NADH oxidase from Streptococcus mutans were applied for the oxidative lactamization of various amino alcohols. Crucial parameters for the efficiency of this cascade reaction were elucidated. This report represents a direct approach for biocatalytic oxidative lactamization reaction.

AB - A direct synthesis of lactams (5-, 6-, and 7-membered) starting from amino-alcohols in a bienzymatic cascade is reported. Horse liver alcohol dehydrogenase together with the NADH oxidase from Streptococcus mutans were applied for the oxidative lactamization of various amino alcohols. Crucial parameters for the efficiency of this cascade reaction were elucidated. This report represents a direct approach for biocatalytic oxidative lactamization reaction.

KW - cofactor regeneration

KW - enzymatic cascades

KW - horse liver alcohol dehydrogenase

KW - lactams

KW - oxidoreductases

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JO - ACS Catalysis

JF - ACS Catalysis

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ER -

Horse Liver Alcohol Dehydrogenase-Catalyzed Oxidative Lactamization of Amino Alcohols

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Keywords

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