Horse Liver Alcohol Dehydrogenase-Catalyzed Oxidative Lactamization of Amino Alcohols

Lei Huang, Giovanni Vallian Sayoga, Frank Hollmann, Selin Kara

Research output: Contribution to journalArticleScientificpeer-review

12 Citations (Scopus)
22 Downloads (Pure)

Abstract

A direct synthesis of lactams (5-, 6-, and 7-membered) starting from amino-alcohols in a bienzymatic cascade is reported. Horse liver alcohol dehydrogenase together with the NADH oxidase from Streptococcus mutans were applied for the oxidative lactamization of various amino alcohols. Crucial parameters for the efficiency of this cascade reaction were elucidated. This report represents a direct approach for biocatalytic oxidative lactamization reaction.

Original languageEnglish
Pages (from-to)8680-8684
Number of pages5
JournalACS Catalysis
Volume8
Issue number9
DOIs
Publication statusPublished - 2018

Keywords

  • cofactor regeneration
  • enzymatic cascades
  • horse liver alcohol dehydrogenase
  • lactams
  • oxidoreductases

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