Abstract
A direct synthesis of lactams (5-, 6-, and 7-membered) starting from amino-alcohols in a bienzymatic cascade is reported. Horse liver alcohol dehydrogenase together with the NADH oxidase from Streptococcus mutans were applied for the oxidative lactamization of various amino alcohols. Crucial parameters for the efficiency of this cascade reaction were elucidated. This report represents a direct approach for biocatalytic oxidative lactamization reaction.
Original language | English |
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Pages (from-to) | 8680-8684 |
Number of pages | 5 |
Journal | ACS Catalysis |
Volume | 8 |
Issue number | 9 |
DOIs | |
Publication status | Published - 2018 |
Keywords
- cofactor regeneration
- enzymatic cascades
- horse liver alcohol dehydrogenase
- lactams
- oxidoreductases