H2as a fuel for flavin- And H2O2-dependent biocatalytic reactions

Ammar Al-Shameri; Sébastien J.P. Willot; Caroline E. Paul; Frank Hollmann; Lars Lauterbach

doi:10.1039/d0cc03229h

H₂as a fuel for flavin- And H₂O₂-dependent biocatalytic reactions

Ammar Al-Shameri, Sébastien J.P. Willot, Caroline E. Paul, Frank Hollmann, Lars Lauterbach^*

^*Corresponding author for this work

BT/Biocatalysis

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Abstract

The soluble hydrogenase from Ralstonia eutropha provides an atom efficient regeneration system for reduced flavin cofactors using H2 as an electron source. We demonstrated this system for highly selective ene-reductase-catalyzed CC-double bond reductions and monooxygenase-catalyzed epoxidation. Reactions were expanded to aerobic conditions to supply H2O2 for peroxygenase-catalyzed hydroxylations.

Original language	English
Pages (from-to)	9667-9670
Journal	Chemical Communications
Volume	56
Issue number	67
DOIs	https://doi.org/10.1039/d0cc03229h
Publication status	Published - 2020

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10.1039/d0cc03229h

d0cc03229hFinal published version, 1.89 MBLicence: CC BY

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title = "H2as a fuel for flavin- And H2O2-dependent biocatalytic reactions",

abstract = "The soluble hydrogenase from Ralstonia eutropha provides an atom efficient regeneration system for reduced flavin cofactors using H2 as an electron source. We demonstrated this system for highly selective ene-reductase-catalyzed CC-double bond reductions and monooxygenase-catalyzed epoxidation. Reactions were expanded to aerobic conditions to supply H2O2 for peroxygenase-catalyzed hydroxylations.",

author = "Ammar Al-Shameri and Willot, {S{\'e}bastien J.P.} and Paul, {Caroline E.} and Frank Hollmann and Lars Lauterbach",

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AU - Al-Shameri, Ammar

AU - Willot, Sébastien J.P.

AU - Paul, Caroline E.

AU - Hollmann, Frank

AU - Lauterbach, Lars

PY - 2020

Y1 - 2020

N2 - The soluble hydrogenase from Ralstonia eutropha provides an atom efficient regeneration system for reduced flavin cofactors using H2 as an electron source. We demonstrated this system for highly selective ene-reductase-catalyzed CC-double bond reductions and monooxygenase-catalyzed epoxidation. Reactions were expanded to aerobic conditions to supply H2O2 for peroxygenase-catalyzed hydroxylations.

AB - The soluble hydrogenase from Ralstonia eutropha provides an atom efficient regeneration system for reduced flavin cofactors using H2 as an electron source. We demonstrated this system for highly selective ene-reductase-catalyzed CC-double bond reductions and monooxygenase-catalyzed epoxidation. Reactions were expanded to aerobic conditions to supply H2O2 for peroxygenase-catalyzed hydroxylations.

UR - http://www.scopus.com/inward/record.url?scp=85089787689&partnerID=8YFLogxK

U2 - 10.1039/d0cc03229h

DO - 10.1039/d0cc03229h

M3 - Article

C2 - 32696786

SN - 1359-7345

VL - 56

SP - 9667

EP - 9670

JO - Chemical Communications

JF - Chemical Communications

IS - 67

ER -

H₂as a fuel for flavin- And H₂O₂-dependent biocatalytic reactions

Abstract

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