Hydrogen peroxide driven biocatalysis

B. O. Burek, S. Bormann, F. Hollmann, J. Z. Bloh, D. Holtmann*

*Corresponding author for this work

Research output: Contribution to journalReview articleScientificpeer-review

85 Citations (Scopus)
52 Downloads (Pure)

Abstract

In general, hydrogen peroxide is a stable and relatively mild oxidant and it can be regarded as the ultimate "green" reagent because water and oxygen are the only by-products. Besides the direct application of H2O2 in chemical processes more and more enzymatic syntheses based on hydrogen peroxide were developed. Different types of reactions can be addressed by using a hydrogen-peroxide driven biocatalysis (e.g. hydroxylations, epoxidations, sulfoxidations, halogenations, Baeyer-Villiger oxidations, decarboxylations). H2O2-driven reactions can often be used to substitute NAD(P)H dependent reactions. Therefore, laborious cofactor regeneration systems can be avoided by using H2O2-dependent enzymes. The tremendous increase in the number of publications dealing with this type of reactions clearly demonstrates the progress in this area in recent years. The described innovations range from new enzymes and types of reaction to novel reaction engineering approaches. This review aims to give the scope of possible advantageous applications of peroxyzymes and a critical discussion of their current limitations. The versatile reactions, the ecological advantageous and the great progress in the discovery and engineering of novel enzymes make a technical use feasible.

Original languageEnglish
Pages (from-to)3232-3249
JournalGreen Chemistry
Volume21
Issue number12
DOIs
Publication statusPublished - 2019

Bibliographical note

Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.

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