Abstract
Single-photon emission computed tomography (SPECT) is a well-established nuclear imaging modality for studying functional and pathological properties of the brain. Conventional general purpose SPECT systems typically offer a spatial resolution of about 10 mm with a sensitivity of 0.01-0.02%. A few dedicated brain SPECT scanners have been proposed, but resolutions and sensitivities are no better than 7 mm and 0.03% respectively, and some of these scanners are not manufactured anymore. This limited resolution hampers detection of localized brain abnormalities, while the low sensitivity requires a long scanning time that limits fast dynamic studies. Besides a compromised resolution and sensitivity, conventional SPECT systems require rotation of heavy detectors to obtain sufficient angular projections, which hamper fast dynamic imaging.
Original language | English |
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Qualification | Doctor of Philosophy |
Awarding Institution |
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Supervisors/Advisors |
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Award date | 13 Jul 2021 |
Electronic ISBNs | 978-94-6384-232-7 |
DOIs | |
Publication status | Published - 2021 |
Keywords
- brain SPECT
- pinhole collimation
- DaTscan
- sufficient sampling
- convolutional neural network
- Monte Carlo simulation