Image Acquisition and Attenuation Map Estimation for Multi-pinhole Clinical SPECT

Y. Chen

Research output: ThesisDissertation (TU Delft)

60 Downloads (Pure)


Single-photon emission computed tomography (SPECT) is a well-established nuclear imaging modality for studying functional and pathological properties of the brain. Conventional general purpose SPECT systems typically offer a spatial resolution of about 10 mm with a sensitivity of 0.01-0.02%. A few dedicated brain SPECT scanners have been proposed, but resolutions and sensitivities are no better than 7 mm and 0.03% respectively, and some of these scanners are not manufactured anymore. This limited resolution hampers detection of localized brain abnormalities, while the low sensitivity requires a long scanning time that limits fast dynamic studies. Besides a compromised resolution and sensitivity, conventional SPECT systems require rotation of heavy detectors to obtain sufficient angular projections, which hamper fast dynamic imaging.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Delft University of Technology
  • Beekman, F.J., Supervisor
  • Goorden, M.C., Advisor
Award date13 Jul 2021
Electronic ISBNs978-94-6384-232-7
Publication statusPublished - 2021


  • brain SPECT
  • pinhole collimation
  • DaTscan
  • sufficient sampling
  • convolutional neural network
  • Monte Carlo simulation


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