Verbesserung der Biokompatibilität von Silikonimplantaten durch Spinnenseidenbeschichtung: Immunhistochemische Untersuchungen zum Einfluss auf die Kapselbildung

Translated title of the contribution: Improving the Biocompatibility of Silicone Implants Using Spider Silk Coatings: Immunohistochemical Analysis of Capsule Formation

Philip Helge Zeplin*, A. K. Berninger, N. C. Maksimovikj, P. Van Gelder, T. Scheibel, H. Walles

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

19 Citations (Scopus)

Abstract

Introduction: Optimisation of the biocompatibility of silicone implants and reduction of capsule formation around the surface of such implants are in the focus of plastic surgical biomaterial research. In addition to its extraordinary physical and biochemical properties, spider silk shows high biocompatibility. Therefore, the coating of silicone implant surfaces with recombinant spider silk was analysed regarding foreign body reactions. Materials and Methods: In the context of a preclinical study, miniaturised silicone implants were implanted in the back of 60 Sprague-Dawley rats. The animals were randomised; 30 animals received a texturised implant coated with the recombinant spider silk protein eADF4(C16) and 30 animals received uncoated implants. 3, 6 and 12 months after implantation, implants together with the surrounding capsules were removed and submitted to histological and immunohistochemical assessment. Results: Coating of silicone implants with the recombinant spider silk protein eADF4(C16) resulted in a delayed and significantly decreased foreign body reaction and a reduced capsule manifestation. Conclusion: eADF4(C16) seems to be a promising candidate for the reduction of foreign body-associated capsule formation. Moreover, coating of other medical implants with this recombinant spider silk protein may improve their biocompatibility with little additional effort.

Translated title of the contributionImproving the Biocompatibility of Silicone Implants Using Spider Silk Coatings: Immunohistochemical Analysis of Capsule Formation
Original languageGerman
Pages (from-to)336-341
Number of pages6
JournalHandchirurgie Mikrochirurgie Plastische Chirurgie
Volume46
Issue number6
DOIs
Publication statusPublished - 1 Dec 2014

Keywords

  • capsular fibrosis
  • foreign body reaction
  • recombinant spider silk
  • silicone implant
  • Wilflingseder score

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