In Phantom Validation of Time-Domain Near-Infrared Optical Tomography Pioneer for Imaging Brain Hypoxia and Hemorrhage

J. Jiang; S. Lindner; A. Di Costanzo-Mata; C. Zhang; E. Charbon; M. Wolf; A. Kalyanov

doi:10.1007/978-3-030-48238-1_54

In Phantom Validation of Time-Domain Near-Infrared Optical Tomography Pioneer for Imaging Brain Hypoxia and Hemorrhage

J. Jiang, S. Lindner, A. Di Costanzo-Mata, C. Zhang, E. Charbon, M. Wolf, A. Kalyanov^*

^*Corresponding author for this work

Research output: Chapter in Book/Conference proceedings/Edited volume › Chapter › Scientific › peer-review

2 Citations (Scopus)

Abstract

The neonatal brain is a vulnerable organ, and lesions due to hemorrhage and/or ischemia occur frequently in preterm neonates. Even though neuroprotective therapies exist, there is no tool available to detect the ischemic lesions. To address this problem, we have recently designed and built the new time-domain near-infrared optical tomography (TD NIROT) system – Pioneer. Here we present the results of a phantom study of the system performance. We used silicone phantoms to mimic risky situations for brain lesions: hemorrhage and hypoxia. Employing Pioneer, we were able to reconstruct accurately both position and optical properties of these inhomogeneities.

Original language	English
Title of host publication	Oxygen transport to Tissue XLII
Editors	E.M. Nemoto
Publisher	SpringerOpen
Pages	341-346
Number of pages	6
ISBN (Electronic)	978-3-030-48238-1-54
DOIs	https://doi.org/10.1007/978-3-030-48238-1_54
Publication status	Published - 2021

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	1269
ISSN (Print)	0065-2598
ISSN (Electronic)	2214-8019

Keywords

Diffuse optical tomography
Preterm brain imaging
Time-domain near-infrared optical tomography (TD NITOR)
Tissue optical properties reconstruction
Tissue oxygenation

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Jiang, J., Lindner, S., Di Costanzo-Mata, A., Zhang, C., Charbon, E., Wolf, M., & Kalyanov, A. (2021). In Phantom Validation of Time-Domain Near-Infrared Optical Tomography Pioneer for Imaging Brain Hypoxia and Hemorrhage. In E. M. Nemoto (Ed.), Oxygen transport to Tissue XLII (pp. 341-346). (Advances in Experimental Medicine and Biology; Vol. 1269). SpringerOpen. https://doi.org/10.1007/978-3-030-48238-1_54

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title = "In Phantom Validation of Time-Domain Near-Infrared Optical Tomography Pioneer for Imaging Brain Hypoxia and Hemorrhage",

abstract = "The neonatal brain is a vulnerable organ, and lesions due to hemorrhage and/or ischemia occur frequently in preterm neonates. Even though neuroprotective therapies exist, there is no tool available to detect the ischemic lesions. To address this problem, we have recently designed and built the new time-domain near-infrared optical tomography (TD NIROT) system – Pioneer. Here we present the results of a phantom study of the system performance. We used silicone phantoms to mimic risky situations for brain lesions: hemorrhage and hypoxia. Employing Pioneer, we were able to reconstruct accurately both position and optical properties of these inhomogeneities.",

keywords = "Diffuse optical tomography, Preterm brain imaging, Time-domain near-infrared optical tomography (TD NITOR), Tissue optical properties reconstruction, Tissue oxygenation",

author = "J. Jiang and S. Lindner and {Di Costanzo-Mata}, A. and C. Zhang and E. Charbon and M. Wolf and A. Kalyanov",

year = "2021",

doi = "10.1007/978-3-030-48238-1_54",

language = "English",

series = "Advances in Experimental Medicine and Biology",

publisher = "SpringerOpen",

pages = "341--346",

editor = "E.M. Nemoto",

booktitle = "Oxygen transport to Tissue XLII",

}

Jiang, J, Lindner, S, Di Costanzo-Mata, A, Zhang, C, Charbon, E, Wolf, M & Kalyanov, A 2021, In Phantom Validation of Time-Domain Near-Infrared Optical Tomography Pioneer for Imaging Brain Hypoxia and Hemorrhage. in EM Nemoto (ed.), Oxygen transport to Tissue XLII. Advances in Experimental Medicine and Biology, vol. 1269, SpringerOpen, pp. 341-346. https://doi.org/10.1007/978-3-030-48238-1_54

In Phantom Validation of Time-Domain Near-Infrared Optical Tomography Pioneer for Imaging Brain Hypoxia and Hemorrhage. / Jiang, J.; Lindner, S.; Di Costanzo-Mata, A. et al.
Oxygen transport to Tissue XLII. ed. / E.M. Nemoto. SpringerOpen, 2021. p. 341-346 (Advances in Experimental Medicine and Biology; Vol. 1269).

Research output: Chapter in Book/Conference proceedings/Edited volume › Chapter › Scientific › peer-review

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AU - Zhang, C.

AU - Charbon, E.

AU - Wolf, M.

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AB - The neonatal brain is a vulnerable organ, and lesions due to hemorrhage and/or ischemia occur frequently in preterm neonates. Even though neuroprotective therapies exist, there is no tool available to detect the ischemic lesions. To address this problem, we have recently designed and built the new time-domain near-infrared optical tomography (TD NIROT) system – Pioneer. Here we present the results of a phantom study of the system performance. We used silicone phantoms to mimic risky situations for brain lesions: hemorrhage and hypoxia. Employing Pioneer, we were able to reconstruct accurately both position and optical properties of these inhomogeneities.

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KW - Preterm brain imaging

KW - Time-domain near-infrared optical tomography (TD NITOR)

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KW - Tissue oxygenation

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In Phantom Validation of Time-Domain Near-Infrared Optical Tomography Pioneer for Imaging Brain Hypoxia and Hemorrhage

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