In Phantom Validation of Time-Domain Near-Infrared Optical Tomography Pioneer for Imaging Brain Hypoxia and Hemorrhage

J. Jiang, S. Lindner, A. Di Costanzo-Mata, C. Zhang, E. Charbon, M. Wolf, A. Kalyanov*

*Corresponding author for this work

Research output: Chapter in Book/Conference proceedings/Edited volumeChapterScientificpeer-review

1 Citation (Scopus)

Abstract

The neonatal brain is a vulnerable organ, and lesions due to hemorrhage and/or ischemia occur frequently in preterm neonates. Even though neuroprotective therapies exist, there is no tool available to detect the ischemic lesions. To address this problem, we have recently designed and built the new time-domain near-infrared optical tomography (TD NIROT) system – Pioneer. Here we present the results of a phantom study of the system performance. We used silicone phantoms to mimic risky situations for brain lesions: hemorrhage and hypoxia. Employing Pioneer, we were able to reconstruct accurately both position and optical properties of these inhomogeneities.

Original languageEnglish
Title of host publicationOxygen transport to Tissue XLII
EditorsE.M. Nemoto
PublisherSpringer Open
Pages341-346
Number of pages6
ISBN (Electronic)978-3-030-48238-1-54
DOIs
Publication statusPublished - 2021

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1269
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Diffuse optical tomography
  • Preterm brain imaging
  • Time-domain near-infrared optical tomography (TD NITOR)
  • Tissue optical properties reconstruction
  • Tissue oxygenation

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