In vitro and in silico modeling of endovascular stroke treatments for acute ischemic stroke

Giulia Luraghi, Rachel M.E. Cahalane, Emma van de Ven, Serena C.M. Overschie, Frank J.H. Gijsen, Ali C. Akyildiz

Research output: Contribution to journalReview articlepeer-review

Abstract

Acute ischemic stroke occurs when a thrombus obstructs a cerebral artery, leading to sub-optimal blood perfusion to brain tissue. A recently developed, preventive treatment is the endovascular stroke treatment (EVT), which is a minimally invasive procedure, involving the use of stent-retrievers and/or aspiration catheters. Despite its increasing use, many critical factors of EVT are not well understood. In this respect, in vitro, and in silico studies have the great potential to help us deepen our understanding of the procedure, perform further device and procedural optimization, and help in clinical training. This review paper provides an overview of the previous in vitro and in silico evaluations of EVT treatments, with a special emphasis on the four main aspects of the adopted experimental and numerical set-ups: vessel, thrombus, device, and procedural settings.

Original languageEnglish
Article number110693
Number of pages10
JournalJournal of Biomechanics
Volume127
DOIs
Publication statusPublished - 2021

Keywords

  • Acute ischemic stroke
  • Aspiration
  • Stent-retriever
  • Thrombectomy

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