In vivo electric conductivity of cervical cancer patients based on B 1+ maps at 3T MRI

E Balidemaj, P de Boer, ALHMW van Lier, RF Remis, LJA Stalpers, GH Westerveld, AAJ Nederveen, CAT van den Berg, J Crezee

Research output: Contribution to journalArticleScientificpeer-review

32 Citations (Scopus)

Abstract

The in vivo electric conductivity (σ) values of tissue are essential for accurate electromagnetic simulations and specific absorption rate (SAR) assessment for applications such as thermal dose computations in hyperthermia. Currently used σ-values are mostly based on ex vivo measurements. In this study the conductivity of human muscle, bladder content and cervical tumors is acquired non-invasively in vivo using MRI. The conductivity of 20 cervical cancer patients was measured with the MR-based electric properties tomography method on a standard 3T MRI system. The average in vivo σ-value of muscle is 14% higher than currently used in human simulation models. The σ-value of bladder content is an order of magnitude higher than the value for bladder wall tissue that is used for the complete bladder in many models. Our findings are confirmed by various in vivo animal studies from the literature. In cervical tumors, the observed average conductivity was 13% higher than the literature value reported for cervical tissue. Considerable deviations were found for the electrical conductivity observed in this study and the commonly used values for SAR assessment, emphasizing the importance of acquiring in vivo conductivity for more accurate SAR assessment in various applications.
Original languageEnglish
Pages (from-to)1596-1607
Number of pages12
JournalPhysics in Medicine and Biology
Volume61
Issue number4
DOIs
Publication statusPublished - 2016

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