Influence of Glycyl-L-Glutamic Acid Dipeptide on Calcium Pyrophosphate Dihydrate Crystallization

Sevgi Polat*, Qi An, Huseyin Burak Eral

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

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The increasing prevalence of calcium pyrophosphate dihydrate (CPPD) deposition disease, a form of arthritis with high inflammatory potential, has triggered considerable interest in the search for additives to prevent CPPD crystal formation, particularly in the field of biomineralization. In this context, CPPD crystallization in aqueous solution with and without glycine, glutamic acid, or glycyl-L-glutamic acid as crystal-growth modifier was experimentally investigated. The produced crystals were characterized structurally, morphologically, and in terms of their surface charge. In addition, the thermal degradation profiles of CPPD crystals obtained with and without the modifiers were characterized by TGA-FTIR, and the major volatile product was H2O.

Original languageEnglish
Pages (from-to)2301-2309
JournalChemical Engineering and Technology
Issue number11
Publication statusPublished - 2023


  • Calcium pyrophosphate dihydrate
  • Crystallization
  • Morphology
  • Peptides
  • Thermogravimetric analysis


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