Influence of polymer coating on release of l-dopa from core-shell Fe@Au nanoparticle systems

Sulalit Bandyopadhyay, Muhammad Awais Ashfaq Alvi, Anuvansh Sharma, Kaizheng Zhu, Anna Lena Kjøniksen, Bo Nyström, Wilhelm Robert Glomm

Research output: Contribution to journalArticleScientificpeer-review

1 Citation (Scopus)


We report on the effect of different stimuli-responsive polymer shells on Fe@Au core-shell nanoparticles (NPs) with respect to thermoresponse as well as loading and release characteristics. The hybrid NP systems were investigated using a wide array of characterization techniques including dynamic light scattering, electrophoretic mobility, UV-visible spectroscopy, and scanning transmission electron microscopy. Three different polymeric shells were selected for loading and release of l-dopa: thiolated polyethylene glycol (PEG), poly(N-isopropylacrylamide-co-acrylic acid) (PNIPAAM_AAc) microgel crosslinked with N,N′-methylenebis(acrylamide) (BIS), and finally concomitant PEG and PNIPAAM_AAc microgel (Fe@Au_PEG_Microgel). All three shells were found to exhibit high loading (∼10%) and encapsulation efficiencies up to 100 μg l-dopa/mg. Although the loading efficiencies are comparable for the three systems, Fe@Au_PEG_Microgel has the highest release (87%) at elevated temperature and acidic conditions. The attenuated release from the PEG-based systems can be attributed to stronger dipole-dipole interactions between the carboxyl group of PEG and the amino group of l-dopa. [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)391-402
Number of pages12
JournalColloid and Polymer Science: Kolloid-Zeitschrift und Zeitschrift für Polymere
Issue number2
Publication statusPublished - 1 Feb 2017
Externally publishedYes


  • Core-shell nanoparticles
  • Fe@Au
  • l-dopa
  • Microgels
  • Thermoresponse

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