Infrared spectroscopic examination of aqueous humor

David Weissbrodt; Ralf Mueller; Jessica Perrin; Juergen Backhaus; Jost B. Jonas

doi:10.1089/jop.2006.0051

Infrared spectroscopic examination of aqueous humor

David Weissbrodt, Ralf Mueller, Jessica Perrin, Juergen Backhaus, Jost B. Jonas^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

2 Citations (Scopus)

Abstract

Objective: The aim of this study was to report on a new technique for examining aqueous humor. Participants: Aqueous humor samples obtained from 198 patients (cataract: n = 66 eyes; age-related macular degeneration [AMD]: n = 66; diabetic macular edema: n = 66) were in vitro examined by mid infrared spectroscopy. After training and validating the technique, 66 samples were taken for the final independent prediction. Results: In computerized analysis of the spectrometric data, 22 (100%) cataract eyes were diagnosed as the cataract group, 17 (77%) diabetic macular edema eyes were diagnosed as the diabetic macular edema group, and 14 (64%) eyes with AMD were diagnosed as the AMD group. Mid infrared spectrometry could statistically significantly (P = 0.004) differentiate between the 3 study groups. Conclusions: Mid infrared spectroscopic examination of aqueous humor may be able to differentiate eyes with cataract, AMD, or diabetic macular edema.

Original language	English
Pages (from-to)	54-56
Number of pages	3
Journal	Journal of Ocular Pharmacology and Therapeutics
Volume	23
Issue number	1
DOIs	https://doi.org/10.1089/jop.2006.0051
Publication status	Published - Feb 2007

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10.1089/jop.2006.0051

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title = "Infrared spectroscopic examination of aqueous humor",

abstract = "Objective: The aim of this study was to report on a new technique for examining aqueous humor. Participants: Aqueous humor samples obtained from 198 patients (cataract: n = 66 eyes; age-related macular degeneration [AMD]: n = 66; diabetic macular edema: n = 66) were in vitro examined by mid infrared spectroscopy. After training and validating the technique, 66 samples were taken for the final independent prediction. Results: In computerized analysis of the spectrometric data, 22 (100%) cataract eyes were diagnosed as the cataract group, 17 (77%) diabetic macular edema eyes were diagnosed as the diabetic macular edema group, and 14 (64%) eyes with AMD were diagnosed as the AMD group. Mid infrared spectrometry could statistically significantly (P = 0.004) differentiate between the 3 study groups. Conclusions: Mid infrared spectroscopic examination of aqueous humor may be able to differentiate eyes with cataract, AMD, or diabetic macular edema.",

author = "David Weissbrodt and Ralf Mueller and Jessica Perrin and Juergen Backhaus and Jonas, {Jost B.}",

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T1 - Infrared spectroscopic examination of aqueous humor

AU - Weissbrodt, David

AU - Mueller, Ralf

AU - Perrin, Jessica

AU - Backhaus, Juergen

AU - Jonas, Jost B.

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N2 - Objective: The aim of this study was to report on a new technique for examining aqueous humor. Participants: Aqueous humor samples obtained from 198 patients (cataract: n = 66 eyes; age-related macular degeneration [AMD]: n = 66; diabetic macular edema: n = 66) were in vitro examined by mid infrared spectroscopy. After training and validating the technique, 66 samples were taken for the final independent prediction. Results: In computerized analysis of the spectrometric data, 22 (100%) cataract eyes were diagnosed as the cataract group, 17 (77%) diabetic macular edema eyes were diagnosed as the diabetic macular edema group, and 14 (64%) eyes with AMD were diagnosed as the AMD group. Mid infrared spectrometry could statistically significantly (P = 0.004) differentiate between the 3 study groups. Conclusions: Mid infrared spectroscopic examination of aqueous humor may be able to differentiate eyes with cataract, AMD, or diabetic macular edema.

AB - Objective: The aim of this study was to report on a new technique for examining aqueous humor. Participants: Aqueous humor samples obtained from 198 patients (cataract: n = 66 eyes; age-related macular degeneration [AMD]: n = 66; diabetic macular edema: n = 66) were in vitro examined by mid infrared spectroscopy. After training and validating the technique, 66 samples were taken for the final independent prediction. Results: In computerized analysis of the spectrometric data, 22 (100%) cataract eyes were diagnosed as the cataract group, 17 (77%) diabetic macular edema eyes were diagnosed as the diabetic macular edema group, and 14 (64%) eyes with AMD were diagnosed as the AMD group. Mid infrared spectrometry could statistically significantly (P = 0.004) differentiate between the 3 study groups. Conclusions: Mid infrared spectroscopic examination of aqueous humor may be able to differentiate eyes with cataract, AMD, or diabetic macular edema.

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Infrared spectroscopic examination of aqueous humor

Abstract

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