Innovative Tissue-Engineered Strategies for Osteochondral Defect Repair and Regeneration: Current Progress and Challenges

Liangbin Zhou, G.J.V.M. van Osch, Jos Malda, Martin J. Stoddart, Yuxiao Lai, R. Geoff Richards, Kevin Ki-wai Ho*, Ling Qin

*Corresponding author for this work

Research output: Contribution to journalReview articleScientificpeer-review

13 Citations (Scopus)
13 Downloads (Pure)


Clinical treatments for the repair of osteochondral defects (OCD) are merely palliative, not completely curative, and thus enormously unfulfilled challenges. With the in-depth studies of biology, medicine, materials, and engineering technology, the conception of OCD repair and regeneration should be renewed. During the past decades, many innovative tissue-engineered approaches for repairing and regenerating damaged osteochondral units have been widely explored. Various scaffold-free and scaffold-based strategies, such as monophasic, biphasic, and currently fabricated multiphasic and gradient architectures have been proposed and evaluated. Meanwhile, progenitor cells and tissue-specific cells have also been intensively investigated in vivo as well as ex vivo. Concerning bioactive factors and drugs, they have been combined with scaffolds and/or living cells, and even released in a spatiotemporally controlled manner. Although tremendous progress has been achieved, further research and development (R&D) is needed to convert preclinical outcomes into clinical applications. Here, the osteochondral unit structure, its defect classifications, and diagnosis are summarized. Commonly used clinical reparative techniques, tissue-engineered strategies, emerging 3D-bioprinting technologies, and the status of their clinical applications are discussed. Existing challenges to translation are also discussed and potential solutions for future R&D directions are proposed.

Original languageEnglish
Article number2001008
Number of pages22
JournalAdvanced Healthcare Materials
Issue number23
Publication statusPublished - 2020

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  • clinical applications
  • osteochondral defect repair and regeneration
  • scaffolds
  • tissue-engineered strategies


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