Inspiring process innovation: Via an improved green manufacturing metric: IGAL

Frank Roschangar*, Yanyan Zhou, David J.C. Constable, Juan Colberg, David P. Dickson, Peter J. Dunn, Jason Mulder, Jörg Brandenburg, Roger A. Sheldon, More Authors

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

48 Citations (Scopus)


Following our goal to devise a unified green chemistry metric that inspires innovation in sustainable drug manufacturing across the pharmaceutical industry, we herein disclose joint efforts by IQ, the ACS GCI PR and academia, leading to the significantly improved 'innovation Green Aspiration Level' (iGAL) methodology. Backed by the statistical analysis of 64 drug manufacturing processes encompassing 703 steps across 12 companies, we find that iGAL affords an excellent proxy for molecular complexity and presents a valuable molecular weight-based 'fixed' goal. iGAL thereby accurately captures the impact of green process inventiveness and improvements, making it a useful innovation-driven green metric. We conclude by introducing the comprehensive, yet easy-to-use and readily adaptable Green Chemistry Innovation Scorecard web calculator, whose graphical output clearly and effectively illustrates the impact of innovation on waste reduction during drug manufacture.

Original languageEnglish
Pages (from-to)2206-2211
JournalGreen Chemistry
Issue number10
Publication statusPublished - 2018


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