TY - JOUR
T1 - Interplay between Confinement and Drag Forces Determine the Fate of Amyloid Fibrils
AU - Smith, Kathleen Beth
AU - Wehrli, Monika
AU - Japaridze, Aleksandre
AU - Assenza, Salvatore
AU - Dekker, Cees
AU - Mezzenga, Raffaele
PY - 2020
Y1 - 2020
N2 - The fine interplay between the simultaneous stretching and confinement of amyloid fibrils is probed by combining a microcapillary setup with atomic force microscopy. Single-molecule statistics reveal how the stretching of fibrils changed from force to confinement dominated at different length scales. System order, however, is solely ruled by confinement. Coarse-grained simulations support the results and display the potential to tailor system properties by tuning the two effects. These findings may further help shed light on in vivo amyloid fibril growth and transport in highly confined environments such as blood vessels.
AB - The fine interplay between the simultaneous stretching and confinement of amyloid fibrils is probed by combining a microcapillary setup with atomic force microscopy. Single-molecule statistics reveal how the stretching of fibrils changed from force to confinement dominated at different length scales. System order, however, is solely ruled by confinement. Coarse-grained simulations support the results and display the potential to tailor system properties by tuning the two effects. These findings may further help shed light on in vivo amyloid fibril growth and transport in highly confined environments such as blood vessels.
UR - http://www.scopus.com/inward/record.url?scp=85083042243&partnerID=8YFLogxK
U2 - 10.1103/PhysRevLett.124.118102
DO - 10.1103/PhysRevLett.124.118102
M3 - Article
C2 - 32242730
AN - SCOPUS:85083042243
SN - 0031-9007
VL - 124
JO - Physical Review Letters
JF - Physical Review Letters
IS - 11
M1 - 118102
ER -