Intraventricular blood flow with a fully dynamic mitral valve model

Seyed Saeid Khalafvand*, Fei Xu, Jos Westenberg, Frank Gijsen, Sasa Kenjeres

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

9 Citations (Scopus)


Mitral valve (MV) leaflets affect the formation, growth, and decay of vortices in the left ventricle (LV) during diastolic filling. The shape and motion of MV leaflets are simplified in most studies due to computational restrictions. In this study, we present a newly developed mathematical method to model the dynamic movement of valve leaflets and annulus, which is based on in vivo data obtained with magnetic resonance imaging (MRI). In the present method, we solve a boundary value problem where the MV surface is initially unknown. The resultant MV shapes are included in a dynamic motion model of the LV to assess the change of intraventricular flow patterns. To estimate the effects of the MV on left intraventricular flow, a LV model without MV leaflets was also simulated for comparison. Our study showed that the presence of the MV and the shape of its leaflets significantly altered the formation and evolution of vortex structures in the LV. The various MV leaflet shapes accelerate the transvalvular flow distinctly, leading to different formation and development of vortex structures.

Original languageEnglish
Pages (from-to)197-204
JournalComputers in Biology and Medicine
Publication statusPublished - 2019


  • Blood flow
  • Boundary value problem
  • CFD
  • Dynamic mesh
  • Left ventricle
  • Mitral valve
  • Vortices


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