Joint Estimation of Hemodynamic Response and Stimulus Function in Functional Ultrasound Using Convolutive Mixtures

Aybuke Erol, Simon Van Eyndhoven, Sebastiaan Koekkoek, Pieter Kruizinga, Borbala Hunyadi

Research output: Chapter in Book/Conference proceedings/Edited volumeConference contributionScientificpeer-review

2 Citations (Scopus)
22 Downloads (Pure)

Abstract

Functional ultrasound (fUS) is an exciting new neuroimaging technique that is able to record brain activity similar to functional magnetic resonance imaging, yet with higher spatiotemporal resolution and at lower cost. We consider the problem of jointly estimating the underlying neural sources and the hemodynamic response function (HRF) from fUS recordings. We propose to model the measured voxel time-series as a convolutive mixture of multiple source signals and solve the blind deconvolution problem via block-term decomposition. This allows us to estimate both the source time courses and a different HRF for each voxel and source combination, which accounts for the variability of HRF across different brain regions and events respectively. The proposed approach is proven to be robust against noise via simulations and further validated on real fUS data by performing a visual experiment on a mouse. The obtained results show that the proposed method is able to recover the timings of the visual paradigm.
Original languageEnglish
Title of host publication2020 54th Asilomar Conference on Signals, Systems, and Computers
PublisherIEEE
Pages246-250
Number of pages5
ISBN (Electronic)978-0-7381-3126-9
DOIs
Publication statusPublished - 2020
Event54th Asilomar Conference on Signals, Systems, and Computers - Virtual/online event at Pacific Grove, United States
Duration: 1 Nov 20204 Nov 2020
Conference number: 54
https://www.asilomarsscconf.org/PastConferences.html

Conference

Conference54th Asilomar Conference on Signals, Systems, and Computers
Abbreviated titleACSSC 2020
Country/TerritoryUnited States
CityVirtual/online event at Pacific Grove
Period1/11/204/11/20
Internet address

Bibliographical note

Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care
Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.

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