Lanthanide-Doped Nanoprobes as Orthogonal NIR-II Fluorescence Channels for In Vivo Information Storage

Xiaolu Wang, Qi Jia, Liyi Ma, Xuejiao Zhai, Yuxin Liu, Xianquan Liao, Jing Zhou*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

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Information storage in vivo will lead to next-generation identification and security authentication. Here, an information storage method was proposed for in vivo application by using a pair of lanthanide-doped nanoprobes (NdNPs and ErNPs) with orthogonal emissions in the second near-infrared window. The information is stored in different fluorescence channels separately, while the selective readout could be realized by simply manipulating excitation wavelengths. The small-animal experiments primarily confirm the applicability of this method in vivo. The binary numbers ″1″ and ″0″ are implanted under the mice's skin, and the corresponding signals ″on″ and ″off″ can be collected by charge-coupled devices under different laser filter combinations. The design of lanthanide-doped probes with the nanoscale features and orthogonal emissions is expected to provide a new strategy for information storage in vivo. The lanthanide materials with excellent down-conversion near-infrared fluorescence performance have shown great application potential in the field of photonics.

Original languageEnglish
Pages (from-to)17042-17047
JournalACS Applied Nano Materials
Issue number11
Publication statusPublished - 2022

Bibliographical note

Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.


  • information storage
  • multichannel imaging
  • orthogonal
  • rare earth-based nanoparticles
  • second near-infrared window

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