Laser-driven resonance of dye-doped oil-coated microbubbles: A theoretical and numerical study

Guillaume Lajoinie, Erik Linnartz, Pieter Kruizinga, Nico De Jong, Eleanor Stride, Gijs Van Soest, Michel Versluis

    Research output: Contribution to journalArticleScientificpeer-review

    4 Citations (Scopus)
    42 Downloads (Pure)

    Abstract

    Microbubbles are used to enhance the contrast in ultrasound imaging. When coated with an optically absorbing material, these bubbles can also provide contrast in photoacoustic imaging. This multimodal aspect is of pronounced interest to the field of medical imaging. The aim of this paper is to provide a theoretical framework to describe the physical phenomena underlying the photoacoustic response. This article presents a model for a spherical gas microbubble suspended in an aqueous environment and coated with an oil layer containing an optically absorbing dye. The model includes heat transfer between the gas core and the surrounding liquids. This framework is suitable for the investigation of both continuous wave and pulsed laser excitation. This work utilizes a combination of finite difference simulations and numerical integration to determine the dependancy on the physical properties, including composition and thickness of the oil layer on the microbubble response. A normalization scheme for a linearized version of the model was derived to facilitate comparison with experimental measurements. The results show that viscosity and thickness of the oil layer determine whether or not microbubble resonance can be excited. This work also examines the use of non-sinusoidal excitation to promote harmonic imaging techniques to further improve the imaging sensitivity.

    Original languageEnglish
    Pages (from-to)2727-2745
    Number of pages19
    JournalJournal of the Acoustical Society of America
    Volume141
    Issue number4
    DOIs
    Publication statusPublished - 2017

    Keywords

    • Viscosity
    • Bubble dynamics
    • Ultrasonography
    • Photoacoustic imaging
    • Laser theory

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