Light-Driven Enzymatic Decarboxylation of Fatty Acids

Mieke M.E. Huijbers, Wuyuan Zhang, Fabio Tonin, Frank Hollmann*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

105 Citations (Scopus)
124 Downloads (Pure)

Abstract

The photoenzymatic decarboxylation of fatty acids to alkanes is proposed as an alternative approach for the synthesis of biodiesel. By using a recently discovered photodecarboxylase from Chlorella variabilis NC64A (CvFAP) we demonstrate the irreversible preparation of alkanes from fatty acids and triglycerides. Several fatty acids and their triglycerides are converted by CvFAP in near-quantitative yield and exclusive selectivity upon illumination with blue light. Very promising turnover numbers of up to 8000 were achieved in this proof-of-concept study.

Original languageEnglish
Pages (from-to)13648-13651
JournalAngewandte Chemie - International Edition
Volume57
Issue number41
DOIs
Publication statusPublished - 2018

Bibliographical note

Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.

Keywords

  • biocatalysis
  • biofuels
  • decarboxylation
  • fatty acids
  • photocatalysis

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