Light-Driven Enzymatic Decarboxylation of Fatty Acids

Mieke M.E. Huijbers, Wuyuan Zhang, Fabio Tonin, Frank Hollmann

Research output: Contribution to journalArticleScientificpeer-review

43 Citations (Scopus)
97 Downloads (Pure)


The photoenzymatic decarboxylation of fatty acids to alkanes is proposed as an alternative approach for the synthesis of biodiesel. By using a recently discovered photodecarboxylase from Chlorella variabilis NC64A (CvFAP) we demonstrate the irreversible preparation of alkanes from fatty acids and triglycerides. Several fatty acids and their triglycerides are converted by CvFAP in near-quantitative yield and exclusive selectivity upon illumination with blue light. Very promising turnover numbers of up to 8000 were achieved in this proof-of-concept study.

Original languageEnglish
Pages (from-to)13648-13651
JournalAngewandte Chemie - International Edition
Issue number41
Publication statusPublished - 2018


  • biocatalysis
  • biofuels
  • decarboxylation
  • fatty acids
  • photocatalysis


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