Individual pitch control (IPC) is a well-known approach to reduce blade loads on wind turbines. Although very effective, IPC usually requires high levels of actuator activities, which significantly increases the pitch actuator duty cycle (ADC). This will subsequently result in an increase of the wear on the bearings of the blades and a decrease of the wind turbine reliability. An alternative approach to this issue is to reduce the actuator activities by incorporating the output constraints in IPC. In this paper, a fully data-driven IPC approach, which is called constrained subspace predictive repetitive control (cSPRC), is introduced. The output constraints can be explicitly considered in the control problem formulation via a model predictive control (MPC) approach. The cSPRC approach will actively produce the IPC action for the necessary load reduction when the blade loads violate the output constraints. In this way, actuator activities can be significantly reduced. Two kinds of scenarios are simulated to illustrate the unique applications of the proposed method: wake–rotor overlap and turbulent sheared wind conditions. Simulation results show that the developed cSPRC is able to account for the output constraints into the control problem formulation. Since the IPC action from cSPRC is only triggered to prevent violating the output constraints, the actuator activities are significantly reduced. This will help to reduce the pitch ADC, thus leading to an economical viable load control strategy. In addition, this approach allows the wind farm operator to design conservative bounds to guarantee the safety of the wind turbine control system.