Abstract
In this study, we propose a novel approach for estimation of local activation times (LATs) in fractionated electrograms. Using an electrophysiological tissue model, we first formulate the electrogram array as a convolution of transmembrane currents with a distance kernel. These currents are more local activities and less affected by the heterogeneity in the tissue compared to electrograms. We then deconvolve the distance kernel with the electrograms to reconstruct the transmembrane current. To stabilize the solution of this ill-posed deconvolution, we use spatio-temporal total variation as a regularization. This helps to preserve sharp spatial and temporal deflections in the currents that are of higher importance in LAT estimation. Finally, the maximum negative slope of the reconstructed transmembrane currents are used to estimate the LATs. Instrumental comparison to two reference approaches shows that the proposed approach performs better in estimating the LATs in fractionated electrograms.
Original language | English |
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Title of host publication | 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019 |
Place of Publication | Danvers |
Publisher | IEEE |
Pages | 285-288 |
Number of pages | 4 |
ISBN (Electronic) | 978-1-5386-1311-5 |
ISBN (Print) | 978-1-5386-1312-2 |
DOIs | |
Publication status | Published - 2019 |
Event | EMBC 2019: 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Berlin, Germany Duration: 23 Jul 2019 → 27 Jul 2019 Conference number: 41st |
Publication series
Name | Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS |
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ISSN (Print) | 1557-170X |
Conference
Conference | EMBC 2019 |
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Country/Territory | Germany |
City | Berlin |
Period | 23/07/19 → 27/07/19 |
Bibliographical note
Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-careOtherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public