Low-Noise Integrated Potentiostat for Affinity-Free Protein Detection with 12 nV/rt-Hz at 30 Hz and 1.8 pArms Resolution

Sean Fischer; Dante Muratore; Stephen Weinreich; Aldo Pena-Perez; Ross M. Walker; Chaitanya Gupta; Roger T. Howe; Boris Murmann

doi:10.1109/LSSC.2019.2926644

Low-Noise Integrated Potentiostat for Affinity-Free Protein Detection with 12 nV/rt-Hz at 30 Hz and 1.8 pA^rms Resolution

Sean Fischer^*, Dante Muratore, Stephen Weinreich, Aldo Pena-Perez, Ross M. Walker, Chaitanya Gupta, Roger T. Howe, Boris Murmann

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

This letter presents a low-noise integrated potentiostat for affinity-free molecular detection in applications for personalized medicine. The affinity-free sensing technique uses a digital classifier to identify molecules through unique vibrational signatures. The sensing mechanism relies on coherent interference of electron wave functions at the interface between a nanoscale working electrode and a liquid electrolyte. Coherence at the sensing interface is enabled by low-noise feedback, which reduces the effective temperature of the electrons. The described three-channel potentiostat IC uses chopping and correlated double sampling to achieve an input-referred voltage noise of 12 nV/rt-Hz at 30 Hz and a current resolution of 1.8 pA_rms with 0.5-s averaging time. Each channel consumes 5 mW and occupies 0.41 mm² in 65-nm CMOS.

Original language	English
Article number	8755333
Pages (from-to)	41-44
Number of pages	4
Journal	IEEE Solid-State Circuits Letters
Volume	2
Issue number	6
DOIs	https://doi.org/10.1109/LSSC.2019.2926644
Publication status	Published - 2019
Externally published	Yes

Keywords

Bio-sensing
chopping
correlated double sampling (CDS)
personalized medicine
potentiostat

Access to Document

10.1109/LSSC.2019.2926644

Cite this

@article{680929e084304c618a77d9756523a0c3,

title = "Low-Noise Integrated Potentiostat for Affinity-Free Protein Detection with 12 nV/rt-Hz at 30 Hz and 1.8 pArms Resolution",

abstract = "This letter presents a low-noise integrated potentiostat for affinity-free molecular detection in applications for personalized medicine. The affinity-free sensing technique uses a digital classifier to identify molecules through unique vibrational signatures. The sensing mechanism relies on coherent interference of electron wave functions at the interface between a nanoscale working electrode and a liquid electrolyte. Coherence at the sensing interface is enabled by low-noise feedback, which reduces the effective temperature of the electrons. The described three-channel potentiostat IC uses chopping and correlated double sampling to achieve an input-referred voltage noise of 12 nV/rt-Hz at 30 Hz and a current resolution of 1.8 pArms with 0.5-s averaging time. Each channel consumes 5 mW and occupies 0.41 mm2 in 65-nm CMOS.",

keywords = "Bio-sensing, chopping, correlated double sampling (CDS), personalized medicine, potentiostat",

author = "Sean Fischer and Dante Muratore and Stephen Weinreich and Aldo Pena-Perez and Walker, {Ross M.} and Chaitanya Gupta and Howe, {Roger T.} and Boris Murmann",

year = "2019",

doi = "10.1109/LSSC.2019.2926644",

language = "English",

volume = "2",

pages = "41--44",

journal = "IEEE Solid-State Circuits Letters",

issn = "2573-9603",

publisher = "IEEE",

number = "6",

}

TY - JOUR

T1 - Low-Noise Integrated Potentiostat for Affinity-Free Protein Detection with 12 nV/rt-Hz at 30 Hz and 1.8 pArms Resolution

AU - Fischer, Sean

AU - Muratore, Dante

AU - Weinreich, Stephen

AU - Pena-Perez, Aldo

AU - Walker, Ross M.

AU - Gupta, Chaitanya

AU - Howe, Roger T.

AU - Murmann, Boris

PY - 2019

Y1 - 2019

N2 - This letter presents a low-noise integrated potentiostat for affinity-free molecular detection in applications for personalized medicine. The affinity-free sensing technique uses a digital classifier to identify molecules through unique vibrational signatures. The sensing mechanism relies on coherent interference of electron wave functions at the interface between a nanoscale working electrode and a liquid electrolyte. Coherence at the sensing interface is enabled by low-noise feedback, which reduces the effective temperature of the electrons. The described three-channel potentiostat IC uses chopping and correlated double sampling to achieve an input-referred voltage noise of 12 nV/rt-Hz at 30 Hz and a current resolution of 1.8 pArms with 0.5-s averaging time. Each channel consumes 5 mW and occupies 0.41 mm2 in 65-nm CMOS.

AB - This letter presents a low-noise integrated potentiostat for affinity-free molecular detection in applications for personalized medicine. The affinity-free sensing technique uses a digital classifier to identify molecules through unique vibrational signatures. The sensing mechanism relies on coherent interference of electron wave functions at the interface between a nanoscale working electrode and a liquid electrolyte. Coherence at the sensing interface is enabled by low-noise feedback, which reduces the effective temperature of the electrons. The described three-channel potentiostat IC uses chopping and correlated double sampling to achieve an input-referred voltage noise of 12 nV/rt-Hz at 30 Hz and a current resolution of 1.8 pArms with 0.5-s averaging time. Each channel consumes 5 mW and occupies 0.41 mm2 in 65-nm CMOS.

KW - Bio-sensing

KW - chopping

KW - correlated double sampling (CDS)

KW - personalized medicine

KW - potentiostat

UR - http://www.scopus.com/inward/record.url?scp=85082544865&partnerID=8YFLogxK

U2 - 10.1109/LSSC.2019.2926644

DO - 10.1109/LSSC.2019.2926644

M3 - Article

AN - SCOPUS:85082544865

SN - 2573-9603

VL - 2

SP - 41

EP - 44

JO - IEEE Solid-State Circuits Letters

JF - IEEE Solid-State Circuits Letters

IS - 6

M1 - 8755333

ER -

Low-Noise Integrated Potentiostat for Affinity-Free Protein Detection with 12 nV/rt-Hz at 30 Hz and 1.8 pA^rms Resolution

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this