Magnetic Resonance Imaging compatible Elastic Loading Mechanism (MELM): A minimal footprint device for MR imaging under load

Jaap Boon; Telly Ploem; Cole S. Simpson; Ingo Hermann; Mehmet Akcakaya; Amir A. Zadpoor; Nazli Tumer; Joao Tourais; Sebastian Weingartner; null More Authors

doi:10.1109/EMBC46164.2021.9630397

Magnetic Resonance Imaging compatible Elastic Loading Mechanism (MELM): A minimal footprint device for MR imaging under load

Jaap Boon, Telly Ploem, Cole S. Simpson, Ingo Hermann, Mehmet Akcakaya, Amir A. Zadpoor, Nazli Tumer, Joao Tourais, Sebastian Weingartner, More Authors

Research output: Chapter in Book/Conference proceedings/Edited volume › Conference contribution › Scientific › peer-review

1 Citation (Scopus)

Abstract

Quantitative Magnetic Resonance Imaging (MRI) can enable early diagnosis of knee cartilage damage if imaging is performed during the application of load. Mechanical loading via ropes, pulleys and suspended weights can be obstructive and require adaptations to the patient table. In this paper, a new lightweight MRI-compatible elastic loading mechanism is introduced. The new device showed sufficient linearity (|α/β| = 0.42 ± 0.25), reproducibility (CoV = 5 ± 2%), and stability (CoV = 0.5 ± 0.1%). In vivo and ex vivo scans confirmed the ability of the device to exert sufficient force to study the knee cartilage under loading conditions, inducing up to a 29% decrease in T2 of the central medial cartilage. With this device mechanical loading can become more accessible for researchers and clinicians, thus facilitating the translational use of MRI biomarkers for the detection of cartilage deterioration.

Original language	English
Title of host publication	43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021
Publisher	IEEE
Pages	3721-3724
ISBN (Electronic)	978-1-7281-1179-7
DOIs	https://doi.org/10.1109/EMBC46164.2021.9630397
Publication status	Published - 2021
Event	43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021 - Virtual, Online, Mexico Duration: 1 Nov 2021 → 5 Nov 2021

Conference

Conference	43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021
Country/Territory	Mexico
City	Virtual, Online
Period	1/11/21 → 5/11/21

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10.1109/EMBC46164.2021.9630397

Cite this

Boon, J., Ploem, T., Simpson, C. S., Hermann, I., Akcakaya, M., Zadpoor, A. A., Tumer, N., Tourais, J., Weingartner, S., & More Authors (2021). Magnetic Resonance Imaging compatible Elastic Loading Mechanism (MELM): A minimal footprint device for MR imaging under load. In 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021 (pp. 3721-3724). IEEE. https://doi.org/10.1109/EMBC46164.2021.9630397

@inproceedings{8028722a619e4af295902278e0c118ae,

title = "Magnetic Resonance Imaging compatible Elastic Loading Mechanism (MELM): A minimal footprint device for MR imaging under load",

abstract = "Quantitative Magnetic Resonance Imaging (MRI) can enable early diagnosis of knee cartilage damage if imaging is performed during the application of load. Mechanical loading via ropes, pulleys and suspended weights can be obstructive and require adaptations to the patient table. In this paper, a new lightweight MRI-compatible elastic loading mechanism is introduced. The new device showed sufficient linearity (|α/β| = 0.42 ± 0.25), reproducibility (CoV = 5 ± 2%), and stability (CoV = 0.5 ± 0.1%). In vivo and ex vivo scans confirmed the ability of the device to exert sufficient force to study the knee cartilage under loading conditions, inducing up to a 29% decrease in T2 of the central medial cartilage. With this device mechanical loading can become more accessible for researchers and clinicians, thus facilitating the translational use of MRI biomarkers for the detection of cartilage deterioration.",

author = "Jaap Boon and Telly Ploem and Simpson, {Cole S.} and Ingo Hermann and Mehmet Akcakaya and Zadpoor, {Amir A.} and Nazli Tumer and Joao Tourais and Sebastian Weingartner and {More Authors}",

year = "2021",

doi = "10.1109/EMBC46164.2021.9630397",

language = "English",

pages = "3721--3724",

booktitle = "43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021",

publisher = "IEEE",

address = "United States",

note = "43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021 ; Conference date: 01-11-2021 Through 05-11-2021",

}

Boon, J, Ploem, T, Simpson, CS, Hermann, I, Akcakaya, M, Zadpoor, AA , Tumer, N , Tourais, J , Weingartner, S & More Authors 2021, Magnetic Resonance Imaging compatible Elastic Loading Mechanism (MELM): A minimal footprint device for MR imaging under load. in 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021. IEEE, pp. 3721-3724, 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021, Virtual, Online, Mexico, 1/11/21. https://doi.org/10.1109/EMBC46164.2021.9630397

Magnetic Resonance Imaging compatible Elastic Loading Mechanism (MELM): A minimal footprint device for MR imaging under load. / Boon, Jaap; Ploem, Telly; Simpson, Cole S. et al.
43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021. IEEE, 2021. p. 3721-3724.

Research output: Chapter in Book/Conference proceedings/Edited volume › Conference contribution › Scientific › peer-review

TY - GEN

T1 - Magnetic Resonance Imaging compatible Elastic Loading Mechanism (MELM)

T2 - 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021

AU - Boon, Jaap

AU - Ploem, Telly

AU - Simpson, Cole S.

AU - Hermann, Ingo

AU - Akcakaya, Mehmet

AU - Zadpoor, Amir A.

AU - Tumer, Nazli

AU - Tourais, Joao

AU - Weingartner, Sebastian

AU - More Authors, null

PY - 2021

Y1 - 2021

N2 - Quantitative Magnetic Resonance Imaging (MRI) can enable early diagnosis of knee cartilage damage if imaging is performed during the application of load. Mechanical loading via ropes, pulleys and suspended weights can be obstructive and require adaptations to the patient table. In this paper, a new lightweight MRI-compatible elastic loading mechanism is introduced. The new device showed sufficient linearity (|α/β| = 0.42 ± 0.25), reproducibility (CoV = 5 ± 2%), and stability (CoV = 0.5 ± 0.1%). In vivo and ex vivo scans confirmed the ability of the device to exert sufficient force to study the knee cartilage under loading conditions, inducing up to a 29% decrease in T2 of the central medial cartilage. With this device mechanical loading can become more accessible for researchers and clinicians, thus facilitating the translational use of MRI biomarkers for the detection of cartilage deterioration.

AB - Quantitative Magnetic Resonance Imaging (MRI) can enable early diagnosis of knee cartilage damage if imaging is performed during the application of load. Mechanical loading via ropes, pulleys and suspended weights can be obstructive and require adaptations to the patient table. In this paper, a new lightweight MRI-compatible elastic loading mechanism is introduced. The new device showed sufficient linearity (|α/β| = 0.42 ± 0.25), reproducibility (CoV = 5 ± 2%), and stability (CoV = 0.5 ± 0.1%). In vivo and ex vivo scans confirmed the ability of the device to exert sufficient force to study the knee cartilage under loading conditions, inducing up to a 29% decrease in T2 of the central medial cartilage. With this device mechanical loading can become more accessible for researchers and clinicians, thus facilitating the translational use of MRI biomarkers for the detection of cartilage deterioration.

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DO - 10.1109/EMBC46164.2021.9630397

M3 - Conference contribution

C2 - 34892045

AN - SCOPUS:85122538225

SP - 3721

EP - 3724

BT - 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021

PB - IEEE

Y2 - 1 November 2021 through 5 November 2021

ER -

Magnetic Resonance Imaging compatible Elastic Loading Mechanism (MELM): A minimal footprint device for MR imaging under load

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