Manipulation, Sampling and Inactivation of the SARS-CoV-2 Virus Using Nonuniform Electric Fields on Micro-Fabricated Platforms: A Review

D. Mantri; L.F.A. Wymenga; J. van Turnhout; H.W. van Zeijl; Kouchi Zhang

doi:10.3390/mi14020345

Manipulation, Sampling and Inactivation of the SARS-CoV-2 Virus Using Nonuniform Electric Fields on Micro-Fabricated Platforms: A Review

D. Mantri^*, L.F.A. Wymenga, J. van Turnhout^*, H.W. van Zeijl, Kouchi Zhang^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

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Abstract

Micro-devices that use electric fields to trap, analyze and inactivate micro-organisms vary in concept, design and application. The application of electric fields to manipulate and inactivate bacteria and single-celled organisms has been described extensively in the literature. By contrast, the effect of such fields on viruses is not well understood. This review explores the possibility of using existing methods for manipulating and inactivating larger viruses and bacteria, for smaller viruses, such as SARS-CoV-2. It also provides an overview of the theoretical background. The findings may be used to implement new ideas and frame experimental parameters that optimize the manipulation, sampling and inactivation of SARS-CoV-2 electrically.

Original language	English
Article number	345
Number of pages	21
Journal	Micromachines
Volume	14
Issue number	2
DOIs	https://doi.org/10.3390/mi14020345
Publication status	Published - 2023

Keywords

micro-electrodes
virus in-activation
virus sampling
virus concentration
SARS-CoV-2
dielectrophoresis

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10.3390/mi14020345

micromachines-14-00345Final published version, 1.37 MBLicence: CC BY

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title = "Manipulation, Sampling and Inactivation of the SARS-CoV-2 Virus Using Nonuniform Electric Fields on Micro-Fabricated Platforms: A Review",

abstract = "Micro-devices that use electric fields to trap, analyze and inactivate micro-organisms vary in concept, design and application. The application of electric fields to manipulate and inactivate bacteria and single-celled organisms has been described extensively in the literature. By contrast, the effect of such fields on viruses is not well understood. This review explores the possibility of using existing methods for manipulating and inactivating larger viruses and bacteria, for smaller viruses, such as SARS-CoV-2. It also provides an overview of the theoretical background. The findings may be used to implement new ideas and frame experimental parameters that optimize the manipulation, sampling and inactivation of SARS-CoV-2 electrically. ",

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author = "D. Mantri and L.F.A. Wymenga and {van Turnhout}, J. and {van Zeijl}, H.W. and Kouchi Zhang",

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T2 - A Review

AU - Mantri, D.

AU - Wymenga, L.F.A.

AU - van Turnhout, J.

AU - van Zeijl, H.W.

AU - Zhang, Kouchi

PY - 2023

Y1 - 2023

N2 - Micro-devices that use electric fields to trap, analyze and inactivate micro-organisms vary in concept, design and application. The application of electric fields to manipulate and inactivate bacteria and single-celled organisms has been described extensively in the literature. By contrast, the effect of such fields on viruses is not well understood. This review explores the possibility of using existing methods for manipulating and inactivating larger viruses and bacteria, for smaller viruses, such as SARS-CoV-2. It also provides an overview of the theoretical background. The findings may be used to implement new ideas and frame experimental parameters that optimize the manipulation, sampling and inactivation of SARS-CoV-2 electrically.

AB - Micro-devices that use electric fields to trap, analyze and inactivate micro-organisms vary in concept, design and application. The application of electric fields to manipulate and inactivate bacteria and single-celled organisms has been described extensively in the literature. By contrast, the effect of such fields on viruses is not well understood. This review explores the possibility of using existing methods for manipulating and inactivating larger viruses and bacteria, for smaller viruses, such as SARS-CoV-2. It also provides an overview of the theoretical background. The findings may be used to implement new ideas and frame experimental parameters that optimize the manipulation, sampling and inactivation of SARS-CoV-2 electrically.

KW - micro-electrodes

KW - virus in-activation

KW - virus sampling

KW - virus concentration

KW - SARS-CoV-2

KW - dielectrophoresis

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DO - 10.3390/mi14020345

M3 - Review article

SN - 2072-666X

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JO - Micromachines

JF - Micromachines

IS - 2

M1 - 345

ER -

Manipulation, Sampling and Inactivation of the SARS-CoV-2 Virus Using Nonuniform Electric Fields on Micro-Fabricated Platforms: A Review

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Keywords

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